Interacciones de Ácido folínico (leucovorina)

Ácido folínico (leucovorina) tiene 38 interacciones documentadas en las etiquetas de la FDA y las hojas informativas que indexamos. Graves: 5; moderadas: 32; leves: 1; casos en los que una etiqueta indica que no hay ninguna interacción significativa: 0. Cada entrada de abajo cita la frase que la respalda. Esta página del medicamento es un punto de partida, no un veredicto sobre su situación.

Interacciones según la etiqueta

Interacciones graves (5)

Ácido fólico (folato)Vitaminas y mineralesGrave
VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (etiqueta de Ácido folínico (leucovorina), Contraindicaciones)
Ácido levofolínico (levoleucovorina)Grave
VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (etiqueta de Ácido folínico (leucovorina), Contraindicaciones)
CapecitabinaantimetabolitoGrave
Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil. (etiqueta de Capecitabina, Interacciones medicamentosas)
Sulfametoxazol y trimetoprimasulfonamidaGrave
Trimethoprim-Sulfamethoxazole Avoid concomitant use of VYKOURA with trimethoprim-sulfamethoxazole . (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
TrimetoprimaantibióticoGrave
Trimethoprim-Sulfamethoxazole Avoid concomitant use of VYKOURA with trimethoprim-sulfamethoxazole . (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)

Interacciones moderadas (32)

Ácido valproicoanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
BrivaracetamanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
Cannabidiol (con receta)anticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
CarbamazepinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
CenobamatoanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
ClobazambenzodiazepinaModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
ClonazepambenzodiazepinaModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
Divalproato de sodio (valproato)anticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
EslicarbazepinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
EtosuximidaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
FelbamatoanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
FenitoínaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
FenobarbitalbarbitúricoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
Fenobarbital, hiosciamina, atropina y escopolaminabarbitúricoModerada
Folic acid in high doses may reduce the effectiveness of certain antiepileptic drugs (e.g., phenobarbital, phenytoin, and primidone) and thereby increase the frequency of seizures. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
Fentermina y topiramatoestimulante del SNCModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
FosfenitoínaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
GabapentinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
LacosamidaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
LamotriginaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
LevetiracetamanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
MesuximidaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
OxaliplatinoModerada
Hemorrhage : Increase frequency of monitoring in patients who are receiving oxaliplatin injection with fluorouracil/leucovorin and oral anticoagulants (5.9) (etiqueta de Oxaliplatino, Advertencias y precauciones)
OxcarbazepinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
PerampanelanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
PirimetaminaantipalúdicoModerada
Folinic acid (leucovorin) should be administered in a dosage of 5 to 15 mg daily (orally, IV, or IM) until normal hematopoiesis is restored. (etiqueta de Pirimetamina, Advertencias)
PregabalinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
PrimidonaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
RufinamidaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
TiagabinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
TopiramatoanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
VigabatrinaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)
ZonisamidaanticonvulsivoModerada
Effects of VYKOURA on Other Drugs Certain Antiepileptic Drugs Increase monitoring for seizure activity in patients taking certain concomitant antiepileptic drugs. (etiqueta de Ácido folínico (leucovorina), Interacciones medicamentosas)

Menciones leves (1)

IrinotecánLeve
5-Fluorouracil (5-FU) and Leucovorin (LV) In a phase 1 clinical study involving irinotecan, 5-fluorouracil (5-FU), and leucovorin (LV) in 26 patients with solid tumors, the disposition of irinotecan was not substantially altered when the drugs were co-administered. (etiqueta de Irinotecán, Interacciones medicamentosas)

Compruebe Ácido folínico (leucovorina) frente a todo lo que toma. Añada su lista completa; todos los pares se comprueban a la vez.

Abrir en el verificador

No es un consejo médico. La gravedad refleja la redacción de la etiqueta, no sus circunstancias. Una señal «grave» puede ser algo habitual bajo supervisión y una «leve» puede ser importante a dosis altas. Consulte a un farmacéutico.