Menthol and methyl salicylate interactions

Menthol and methyl salicylate (Bengay, Icy Hot, Salonpas), a salicylate has 44 documented interactions across the FDA labels and fact sheets we index: 9 major, 33 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Major interactions (9)

  • AspirinNSAIDMajor

    Warnings For external use only Allergy alert: do not use if you are allergic to salicylates (including aspirin) unless directed by a doctor. (Menthol and methyl salicylate label, Warnings)

  • Aspirin and dipyridamoleantiplatelet agentMajor

    Warnings For external use only Allergy alert: do not use if you are allergic to salicylates (including aspirin) unless directed by a doctor. (Menthol and methyl salicylate label, Warnings)

  • CelecoxibNSAIDMajor

    Intervention: The concomitant use of Celecoxib with other NSAIDs or salicylates is not recommended. (Celecoxib label, Drug interactions)

  • DiclofenacNSAIDMajor

    Intervention: The concomitant use of diclofenac with other NSAIDs or salicylates is not recommended. (Diclofenac label, Drug interactions)

  • IbuprofenNSAIDMajor

    Intervention: The concomitant use of ibuprofen with other NSAIDs or salicylates is not recommended. (Ibuprofen label, Drug interactions)

  • IndomethacinNSAIDMajor

    Intervention: The concomitant use of indomethacin with other NSAIDs or salicylates, especially diflunisal, is not recommended. (Indomethacin label, Drug interactions)

  • MeloxicamNSAIDMajor

    Intervention: The concomitant use of meloxicam with other NSAIDs or salicylates is not recommended. (Meloxicam label, Drug interactions)

  • NaproxenNSAIDMajor

    Intervention: The concomitant use of naproxen with other NSAIDs or salicylates is not recommended. (Naproxen label, Drug interactions)

  • Sumatriptan and naproxentriptanMajor

    Intervention: The concomitant use of naproxen with other NSAIDs or salicylates is not recommended. (Sumatriptan and naproxen label, Drug interactions)

Moderate interactions (33)

  • AdapaleneretinoidModerate

    Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with Adapalene Cream, 0.1%. (Adapalene label, Drug interactions)

  • CiprofloxacinfluoroquinoloneModerate

    NSAIDs Use with caution Non-steroidal anti-inflammatory drugs (but not acetyl salicylic acid) in combination of very high doses of quinolones have been shown to provoke convulsions in pre-clinical studies and in postmarketing. (Ciprofloxacin label, Drug interactions)

  • DexamethasonecorticosteroidModerate

    The clearance of salicylates may be increased with concurrent use of corticosteroids. (Dexamethasone label, Drug interactions)

  • Dorzolamidecarbonic anhydrase inhibitorModerate

    High-Dose Salicylate Therapy Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy). (Dorzolamide label, Drug interactions)

  • Dorzolamide and timololcarbonic anhydrase inhibitorModerate

    High-Dose Salicylate Therapy Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide hydrochloride ophthalmic solution, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy). (Dorzolamide and timolol label, Drug interactions)

  • FludrocortisonecorticosteroidModerate

    Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. (Fludrocortisone label, Drug interactions)

  • Furosemideloop diureticModerate

    Salicylates : Risk of salicylate toxicity ( 7.1 ) (Furosemide label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors. (Glimepiride label, Drug interactions)

  • GlipizidesulfonylureaModerate

    …antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, nonsteroidal anti-inflammatory agents, chloramphenicol, probenecid, coumarins, voriconazole, H2 receptor… (Glipizide label, Drug interactions)

  • GlyburidesulfonylureaModerate

    …Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents. (Glyburide label, Drug interactions)

  • GriseofulvinantifungalModerate

    Serum salicylate concentrations may be decreased when griseofulvin is given concomitantly with salicylates. (Griseofulvin label, Drug interactions)

  • HydrocortisonecorticosteroidModerate

    The clearance of salicylates may be increased with concurrent use of corticosteroids; this could lead to decreased salicylate serum levels or increase the risk of salicylate toxicity when corticosteroid is withdrawn. (Hydrocortisone label, Drug interactions)

  • Insulin aspartinsulinModerate

    Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. (Insulin aspart label, Drug interactions)

  • Insulin degludecinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. (Insulin degludec label, Drug interactions)

  • Insulin detemirinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors. (Insulin detemir label, Drug interactions)

  • Insulin glargineinsulinModerate

    …May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT-2 inhibitors. (Insulin glargine label, Drug interactions)

  • Insulin lisproinsulinModerate

    Clinically Significant Drug Interactions with LYUMJEV Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (Insulin lispro label, Drug interactions)

  • Insulin regular (human)insulinModerate

    …agents, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blocking Agents, Disopyramide, Fibrates, Fluoxetine, Monoamine Oxidase Inhibitors, Pentoxifylline, Pramlintide, Salicylates, Somatostatin Analogs (e.g., octreotide), and Sulfonamide Antibiotics Prevention or Management Monitor blood glucose more frequently and modify AFREZZA dosage, as clinically… (Insulin regular (human) label, Drug interactions)

  • KetorolacNSAIDModerate

    Warfarin, Digoxin, Salicylate, and Heparin The in vitro binding of warfarin to plasma proteins is only slightly reduced by ketorolac tromethamine (99.5% control vs 99.3%) when ketorolac plasma concentrations reach 5 to 10 mcg/mL. (Ketorolac label, Drug interactions)

  • Levonorgestrel and ethinyl estradioloral contraceptiveModerate

    Other Drugs Clinical effect Concomitant use of CHCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam. (Levonorgestrel and ethinyl estradiol label, Drug interactions)

  • Levothyroxinethyroid hormoneModerate

    An initial increase in serum FT 4 is followed by return of FT 4 to normal levels with sustained therapeutic serum salicylate concentrations, although total T 4 levels may decrease by as much as 30%. (Levothyroxine label, Drug interactions)

  • Liothyroninethyroid hormoneModerate

    An initial increase in serum FT4 is followed by return of FT4 to normal levels with sustained therapeutic serum salicylate concentrations, although total T4 levels may decrease by as much as 30%. (Liothyronine label, Drug interactions)

  • MethotrexateimmunosuppressantModerate

    Caution should be used when NSAIDs and salicylates are administered concomitantly with lower doses of methotrexate, including XATMEP. (Methotrexate label, Drug interactions)

  • MethylprednisolonecorticosteroidModerate

    The clearance of salicylates may be increased with concurrent use of corticosteroids. (Methylprednisolone label, Drug interactions)

  • Metolazonethiazide diureticModerate

    Salicylates And Other Non-Steroidal Anti-Inflammatory Drugs May decrease the antihypertensive effects of metolazone tablets, USP. (Metolazone label, Drug interactions)

  • NizatidineH2 blockerModerate

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (Nizatidine label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveModerate

    COCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine. (Norgestimate and ethinyl estradiol label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    …sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin Drugs that may decrease phenytoin serum levels Antacids Antacids may affect absorption of phenytoin. (Phenytoin label, Drug interactions)

  • PrednisolonecorticosteroidModerate

    NSAIDS, including aspirin and salicylates: Concomitant use of aspirin or other non-steroidal anti-inflammatory agents and corticosteroids increases the risk of gastrointestinal side effects. (Prednisolone label, Drug interactions)

  • PrednisonecorticosteroidModerate

    NSAIDs including aspirin and salicylates: Increased risk of gastrointestinal side effects. (Prednisone label, Drug interactions)

  • Torsemideloop diureticModerate

    Nonsteroidal Anti-Inflammatory Drugs Because torsemide and salicylates compete for secretion by renal tubules, patients receiving high doses of salicylates may experience salicylate toxicity when torsemide is concomitantly administered. (Torsemide label, Drug interactions)

  • TriamcinolonecorticosteroidModerate

    The clearance of salicylates may be increased with concurrent use of corticosteroids. (Triamcinolone label, Drug interactions)

  • VortioxetineantidepressantModerate

    Coadministration of aspirin 150 mg/day with multiple daily doses of TRINTELLIX had no significant inhibitory effect on platelet aggregation or pharmacokinetics of aspirin and salicylic acid [see Clinical Pharmacology (12.3) ] . (Vortioxetine label, Drug interactions)

Minor mentions (2)

  • EnoxaparinanticoagulantMinor

    These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. (Enoxaparin label, Drug interactions)

  • RepaglinidemeglitinideMinor

    Examples: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, nonsteroidal anti-inflammatory agents (NSAIDs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. (Repaglinide label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.