Interaction Checker

Penicillamine interactions

Penicillamine (Cuprimine, Depen) has 100 documented interactions across the FDA labels and fact sheets we index: 10 major, 58 moderate, 32 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (10)

  • AtovaquoneantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • Atovaquone and proguanilantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • ChloroquineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • CysteamineMajor

    The use of PROCYSBI is contraindicated in patients with a serious hypersensitivity reaction, including anaphylaxis, to penicillamine or cysteamine. (Cysteamine label, Contraindications)

  • HydroxychloroquineQT-prolonging drugMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • MefloquineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • PrimaquineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • PyrimethamineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • QuinineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

  • TafenoquineantimalarialMajor

    Penicillamine should not be used in patients who are receiving concurrently gold therapy, antimalarial or cytotoxic drugs, oxyphenbutazone or phenylbutazone because these drugs are also associated with similar serious hematologic and renal adverse reactions. (Penicillamine label, Precautions)

Moderate interactions (58)

  • AbataceptimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • AbrocitinibJAK inhibitorModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • AdalimumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • AlemtuzumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • AzathioprineimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Azelastine and fluticasoneantihistamineModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • BaricitinibJAK inhibitorModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • BeclomethasonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • BetamethasonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • BudesonidecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Budesonide and formoterolcorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • CiclesonidecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • CladribineantimetaboliteModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • ClobetasolcorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • CyclophosphamideimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • CyclosporineimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • DeflazacortcorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • DesonidecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • DexamethasonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Digoxindigitalis glycosideModerate

    Digoxin Concentrations Decreased Acarbose, Activated Charcoal, Albuterol, Antacids, certain cancer chemotherapy or radiation therapy, Cholestyramine, Colestipol, Exenatide, Kaolin-pectin, Meals High in Bran, Metoclopramide, Miglitol, Neomycin, Penicillamine, Phenytoin, Rifampin, St. (Digoxin label, Drug interactions)

  • Dimethyl fumarateimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Doxylamine and pyridoxineantihistamineModerate

    Patients with Wilson’s disease or cystinuria should be given 25 mg/day of pyridoxine during therapy, since penicillamine increases the requirement for this vitamin. (Penicillamine label, Precautions)

  • EtanerceptimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • EverolimusimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • FingolimodimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • FludrocortisonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • FlunisolidecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • FluocinonidecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • FluticasonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Fluticasone and salmeterolcorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • GuselkumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • HalobetasolcorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • HydrocortisonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • InfliximabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • LeflunomideimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • MercaptopurineantimetaboliteModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • MethotrexateimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • MethylprednisolonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • MometasonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • MycophenolateimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • NatalizumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • OcrelizumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Olopatadine and mometasoneantihistamineModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • Pimecrolimuscalcineurin inhibitorModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • PonesimodimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • PrednisolonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • PrednisonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • RitlecitinibJAK inhibitorModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • RituximabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • SecukinumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • SirolimusimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • TacrolimusimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • TeriflunomideimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • TocilizumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • TofacitinibimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • TriamcinolonecorticosteroidModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • UpadacitinibimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

  • UstekinumabimmunosuppressantModerate

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (Penicillamine label, Warnings)

Minor mentions (32)

  • Amoxicillinpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Amoxicillin and clavulanatepenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Ampicillinpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Ampicillin and sulbactampenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • AzelastineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • CarbinoxamineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • CetirizineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • ChlorpheniramineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • ClemastineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • CyproheptadineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • DesloratadineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • DexchlorpheniramineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Dicloxacillinpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • DimenhydrinateantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • DiphenhydramineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • DoxylamineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • FexofenadineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Hydrocodone and chlorpheniramineopioidMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • HydroxyzineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • LevocetirizineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • LoratadineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • MeclizineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Nafcillinpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • OlopatadineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Oxacillinpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Penicillin Gpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Penicillin Vpenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • Piperacillin and tazobactampenicillin antibioticMinor

    Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (Penicillamine label, Precautions)

  • PromethazineantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Promethazine and codeineopioidMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

  • Promethazine and dextromethorphanantihistamineMinor

    Pruritus and early rash may often be controlled by the concomitant administration of antihistamines. (Penicillamine label, Precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.