Doxylamine and pyridoxine and Penicillamine interaction
Doxylamine and pyridoxine and Penicillamine: the Penicillamine prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Penicillamine (Cuprimine) label · effective 2026-01-26
Patients with Wilson’s disease or cystinuria should be given 25 mg/day of pyridoxine during therapy, since penicillamine increases the requirement for this vitamin.
Patients also may receive benefit from a multivitamin preparation, although there is no evidence that deficiency of any vitamin other than pyridoxine is associated with penicillamine.
Rheumatoid arthritis patients whose nutrition is impaired should also be given a daily supplement of pyridoxine.
Pruritus and early rash may often be controlled by the concomitant administration of antihistamines.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.