Interaction Checker

Sodium phenylbutyrate interactions

Sodium phenylbutyrate (Buphenyl, Pheburane, Olpruva) has 28 documented interactions across the FDA labels and fact sheets we index: 0 major, 27 moderate, 1 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (27)

  • Azelastine and fluticasoneantihistamineModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • BeclomethasonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • BetamethasonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • BudesonidecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • Budesonide and formoterolcorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • CiclesonidecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • ClobetasolcorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • DeflazacortcorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • DesonidecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • DexamethasonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • FludrocortisonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • FlunisolidecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • FluocinonidecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • FluticasonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • Fluticasone and salmeterolcorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • HalobetasolcorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • HaloperidolantipsychoticModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • HydrocortisonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • MethylprednisolonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • MometasonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • Olopatadine and mometasoneantihistamineModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • PrednisolonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • PrednisonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • ProbenecidModerate

    Probenecid : May inhibit renal excretion of metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine; monitor for potential neurotoxicity. (Sodium phenylbutyrate label, Drug interactions)

  • Probenecid and colchicineModerate

    Probenecid : May inhibit renal excretion of metabolites of PHEBURANE including phenylacetate and phenylacetylglutamine; monitor for potential neurotoxicity. (Sodium phenylbutyrate label, Drug interactions)

  • TriamcinolonecorticosteroidModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

  • Valproic acidanticonvulsantModerate

    Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (Sodium phenylbutyrate label, Drug interactions)

Minor mentions (1)

  • Glycerol phenylbutyrateMinor

    In clinical trials in patients with UCDs who had been on sodium phenylbutyrate prior to administration of glycerol phenylbutyrate, adverse reactions of headache, fatigue, symptoms of peripheral neuropathy, seizures, tremor and/or dizziness were reported. (Glycerol phenylbutyrate label, Warnings and precautions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.