Haloperidol and Sodium phenylbutyrate interaction
Haloperidol and Sodium phenylbutyrate: the Sodium phenylbutyrate prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Sodium phenylbutyrate (PHEBURANE) label · effective 2026-07-17
Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely.
Monitor plasma ammonia levels closely when PHEBURANE is used concomitantly with corticosteroids, valproic acid, or haloperidol.
Valproic Acid and Haloperidol Hyperammonemia may be induced by haloperidol and by valproic acid.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.