Tetracycline interactions

Tetracycline (Sumycin, Achromycin), a tetracycline antibiotic has 76 documented interactions across the FDA labels and fact sheets we index: 19 major, 28 moderate, 26 minor, and 3 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (19)

  • AcitretinretinoidMajor

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Tetracycline label, Warnings)

  • AdapaleneretinoidMajor

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Tetracycline label, Warnings)

  • Amoxicillinpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Amoxicillin and clavulanatepenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Ampicillinpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Ampicillin and sulbactampenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • BexaroteneretinoidMajor

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Tetracycline label, Warnings)

  • Demeclocyclinetetracycline antibioticMajor

    CONTRAINDICATIONS This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any of the components of the product formulation. (Demeclocycline label, Contraindications)

  • Dicloxacillinpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Doxycyclinetetracycline antibioticMajor

    Doxycycline hyclate are contraindicated in persons who have shown hypersensitivity to any of the tetracyclines. (Doxycycline label, Contraindications)

  • IsotretinoinretinoidMajor

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Tetracycline label, Warnings)

  • Minocyclinetetracycline antibioticMajor

    EMROSI is contraindicated in patients with a history of hypersensitivity to any of the tetracyclines [see Warnings and Precautions (5.1) ]. (Minocycline label, Contraindications)

  • Nafcillinpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Oxacillinpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Penicillin Gpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Penicillin Vpenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Piperacillin and tazobactampenicillin antibioticMajor

    Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (Tetracycline label, Drug interactions)

  • Tigecyclinetetracycline antibioticMajor

    Avoid use in patients with known hypersensitivity to tetracyclines. (Tigecycline label, Warnings and precautions)

  • TretinoinretinoidMajor

    Concomitant use of isotretinoin and tetracycline should be avoided because isotretinoin, a systemic retinoid, is also known to cause pseudotumor cerebri. (Tetracycline label, Warnings)

Moderate interactions (28)

  • ApixabananticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • ArgatrobananticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • AtovaquoneantimalarialModerate

    • Concomitant administration of tetracycline reduces atovaquone concentrations; use caution when coadministering. (Atovaquone label, Drug interactions)

  • Atovaquone and proguanilantimalarialModerate

    • Tetracycline may reduce atovaquone concentrations; parasitemia should be closely monitored. (Atovaquone and proguanil label, Drug interactions)

  • As with other antibacterial drugs, use of tetracycline hydrochloride may result in overgrowth of nonsusceptible organisms, including fungi. (Bismuth subcitrate, metronidazole, and tetracycline label, Warnings and precautions)

  • BivalirudinanticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • CalciumVitamin and mineralModerate

    Calcium binds these drugs in the gut and can sharply cut how much is absorbed; separate the doses. (NIH Office of Dietary Supplements, Calcium)

  • Calcium acetatephosphate binderModerate

    Calcium acetate capsules may decrease the bioavailability of tetracyclines or fluoroquinolones via this mechanism. (Calcium acetate label, Drug interactions)

  • Cholestyraminebile acid sequestrantModerate

    Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (Cholestyramine label, Drug interactions)

  • Colestipolbile acid sequestrantModerate

    The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (Colestipol label, Drug interactions)

  • DabigatrananticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • EdoxabananticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • EnoxaparinanticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • FondaparinuxanticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • GlimepiridesulfonylureaModerate

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Glimepiride label, Drug interactions)

  • HeparinanticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • IronVitamin and mineralModerate

    Iron binds these drugs in the gut and reduces their absorption; separate the doses. (NIH Office of Dietary Supplements, Iron)

  • Lanthanumphosphate binderModerate

    Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (Lanthanum label, Drug interactions)

  • LomitapideModerate

    Caution should be exercised when JUXTAPID is used with other medications known to have potential for hepatotoxicity, such as isotretinoin, amiodarone, acetaminophen (>4 g/day for ≥3 days/week), methotrexate, tetracyclines, and tamoxifen. (Lomitapide label, Warnings and precautions)

  • MagnesiumVitamin and mineralModerate

    Magnesium-containing supplements and antacids reduce absorption of these drugs; separate the doses by at least two hours. (NIH Office of Dietary Supplements, Magnesium)

  • Pioglitazone and glimepiridethiazolidinedioneModerate

    …antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides,… (Pioglitazone and glimepiride label, Drug interactions)

  • QuinaprilACE inhibitorModerate

    Tetracycline and other drugs that interact with magnesium Simultaneous administration of tetracycline with quinapril hydrochloride reduced the absorption of tetracycline by approximately 28% to 37%, possibly due to the high magnesium content in quinapril tablets. (Quinapril label, Drug interactions)

  • QuinineantimalarialModerate

    Although tetracycline may be concomitantly administered with quinine sulfate, patients should be monitored closely for adverse reactions associated with quinine sulfate. (Quinine label, Drug interactions)

  • RivaroxabananticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • Rocuroniumneuromuscular blockerModerate

    Antibiotics Drugs which may enhance the neuromuscular blocking action of nondepolarizing agents such as Rocuronium Bromide Injection include certain antibiotics (e.g., aminoglycosides; vancomycin; tetracyclines; bacitracin; polymyxins; colistin; and sodium colistimethate). (Rocuronium label, Drug interactions)

  • SucralfateModerate

    Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. (Sucralfate label, Drug interactions)

  • WarfarinanticoagulantModerate

    Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (Tetracycline label, Drug interactions)

  • ZincVitamin and mineralModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

Minor mentions (26)

  • Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Desogestrel and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Drospirenone and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • EstradiolestrogenMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Estradiol and dienogestoral contraceptiveMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • FulvestrantestrogenMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • LevonorgestrelprogestinMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • MedroxyprogesteroneprogestinMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • MegestrolprogestinMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • MifepristoneCYP3A4 inhibitorMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • NorethindroneprogestinMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Norgestimate and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Norgestrel and ethinyl estradioloral contraceptiveMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Omeprazole and sodium bicarbonateproton pump inhibitorMinor

    Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate. (Tetracycline label, Drug interactions)

  • ProgesteroneprogestinMinor

    Concurrent use of tetracycline may render oral contraceptives less effective. (Tetracycline label, Drug interactions)

  • Sodium bicarbonateantacidMinor

    Absorption of tetracyclines is impaired by antacids containing aluminum, calcium or magnesium and preparations containing iron, zinc, or sodium bicarbonate. (Tetracycline label, Drug interactions)

  • Vecuroniumneuromuscular blockerMinor

    The following antibiotics have been associated with various degrees of paralysis: aminoglycosides (such as neomycin, streptomycin, kanamycin, gentamicin, and dihydrostreptomycin); tetracyclines; bacitracin; polymyxin B; colistin; and sodium colistimethate. (Vecuronium label, Precautions)

No significant interaction reported (3)

  • AminophyllinemethylxanthineNo interaction

    …omeprazole prednisone, prednisolone ranitidine rifabutin roxithromycin sorbitol (purgative doses do not inhibit theophylline absorption) sucralfate terbutaline, systemic terfenadine tetracycline tocainide The Effect of Other Drugs on Theophylline Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific… (Aminophylline label, Drug interactions)

  • Cisatracuriumneuromuscular blockerNo interaction

    …additional doses of Cisatracurium Besylate Injection, and to determine whether adjustments need to be made to the dose with subsequent administration. † Examples: aminoglycosides, tetracyclines, bacitracin, polymyxins, lincomycin, clindamycin, colistin, sodium colistimethate Drug or Drug Class Clinical Implications * Succinylcholine The use of succinylcholine… (Cisatracurium label, Drug interactions)

  • TheophyllinemethylxanthineNo interaction

    …ranitidine famotidine rifabutin felodipine roxithromycin finasteride Sorbitol (purgative doses do not inhibit hydrocortisone theophylline absorption) isoflurane sucralfate isoniazid terbutaline, systemic isradipine terfenadine influenza vaccine tetracycline ketoconazole tocainide lomefloxacin * Refer to PRECAUTIONS , Drug Interactions for information regarding table. (Theophylline label, Drug interactions)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.