Interacción de Litio con Olanzapina
Litio con Olanzapina: ambas etiquetas de prescripción advierten sobre esta combinación con el lenguaje más contundente, como una contraindicación, una advertencia en recuadro o la indicación de evitarla.
No combinar sin la orientación de un prescriptor. El lenguaje de la etiqueta que aparece a continuación es el más contundente que usa la FDA.
Qué dicen las etiquetas de la FDA
De la etiqueta de Olanzapina (Zyprexa) · vigente desde 2026-02-11
For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products.
When using ZYPREXA in combination with lithium or valproate, refer to the Contraindications section of the package inserts for those products.
Use in Combination with Fluoxetine, Lithium, or Valproate When using ZYPREXA and fluoxetine in combination, the prescriber should also refer to the Warnings and Precautions section of the package insert for Symbyax.
When using ZYPREXA in combination with lithium or valproate, the prescriber should refer to the Warnings and Precautions sections of the package inserts for lithium or valproate [see Drug Interactions ( 7 )] .
Lithium — Multiple doses of olanzapine (10 mg for 8 days) did not influence the kinetics of lithium.
De la etiqueta de Litio (Lithium Carbonate) · vigente desde 2026-08-16
• Encephalopathic Syndrome: Increased risk in patients treated with lithium and an antipsychotic.
Because of a possible causal relationship between these events and the concomitant administration of lithium and antipsychotics, patients receiving such combined treatment should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear.
Atypical and Typical Antipsychotic Drugs Clinical Impact: Reports of neurotoxic reactions in patients treated with both lithium and an antipsychotic, ranging from extrapyramidal symptoms to neuroleptic malignant syndrome, as well as reports of an encephalopathic syndrome in few patients treated with concomitant therapy [see Warnings and Precautions ( 5.5 )] .
Encephalopathic Syndrome An encephalopathic syndrome, characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and fasting blood glucose, has occurred in patients treated with lithium and an antipsychotic.
This encephalopathic syndrome may be similar to or the same as neuroleptic malignant syndrome (NMS).
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Abrir en el verificadorNo es un consejo médico. Interaction Checker cita el texto de las etiquetas de la FDA y las hojas informativas de los NIH. Que una interacción sea importante en su caso depende de las dosis, el momento de las tomas, la función renal y hepática y otras afecciones. Confírmelo con un farmacéutico o un prescriptor.