हेपरिन के इंटरैक्शन

Anticoagulants and Antiplatelets Ticagrelor Contraindicated during and 2 weeks after TOLSURA treatment. (इट्राकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Anticoagulants: warfarin ↑ warfarin Coadministration with REYATAZ has the potential to produce serious and/or life-threatening bleeding and has not been studied. (एटाज़ानाविर लेबल, दवाओं के इंटरैक्शन)

In these patients another anticoagulant should be used ( 5.1 ). (एडोक्साबैन लेबल, बॉक्स्ड चेतावनी)

WARNING: SPINAL/EPIDURAL HEMATOMAS Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. (एनोक्सापैरिन लेबल, बॉक्स्ड चेतावनी)

Avoid use of heparin after use of andexanet alfa for the reversal of direct Factor Xa inhibitors (apixaban and rivaroxaban). (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Unless contraindicated, administer anticoagulant therapy to patients receiving VELETRI to reduce the risk of pulmonary thromboembolism or systemic embolism through a patent foramen ovale. (एपोप्रोस्टेनोल लेबल, चेतावनियां और सावधानियां)

…Voxilaprevir ↓ velpatasvir ↓ voxilaprevir Coadministration of efavirenz and sofosbuvir/velpatasvir/voxilaprevir is not recommended because it may result in loss of therapeutic effect of sofosbuvir/velpatasvir/voxilaprevir Other agents Anticoagulant:Warfarin ↑ or ↓ warfarin Monitor international normalised ratio (INR) and adjust warfarin dosage if necessary. (एफाविरेंज़ लेबल, दवाओं के इंटरैक्शन)

Aminocaproic acid must not be used in the presence of DIC without concomitant heparin. (एमिनोकैप्रोइक एसिड लेबल, निषेध (कॉन्ट्राइंडिकेशन))

Warfarin Potentiates anticoagulant response and can result in serious or fatal bleeding. (एमियोडेरोन लेबल, दवाओं के इंटरैक्शन)

For women with DCIS and for the reduction in breast cancer incidence in women at high risk, tamoxifen is contraindicated in women who require concomitant warfarin-type anticoagulant therapy or in women with a history of deep vein thrombosis or pulmonary embolus. (टैमोक्सीफेन लेबल, चेतावनियां और सावधानियां)

To reduce this risk, consider coverage with another anticoagulant if PRADAXA is discontinued for a reason other than pathological bleeding or completion of a course of therapy ( 2.6 , 2.7 , 2.8 , 5.1 ). (डैबिगैट्रान लेबल, बॉक्स्ड चेतावनी)

Additional risk factors for bleeding include: body weight <60 kg, propensity to bleed, concomitant use of medications that increase the risk of bleeding (e.g . , warfarin, heparin, fibrinolytic therapy, chronic use of nonsteroidal anti-inflammatory drugs [NSAIDs]) [see Warnings and Precautions (5.1) ] . (प्रासुग्रेल लेबल, बॉक्स्ड चेतावनी)

Protamine sulfate should not be given when bleeding occurs without prior heparin use. (प्रोटामिन लेबल, बॉक्स्ड चेतावनी)

WARNING: SPINAL/EPIDURAL HEMATOMAS Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH), heparinoids, or fondaparinux sodium and are receiving neuraxial anesthesia or undergoing spinal puncture. (फोंडापैरिनक्स लेबल, बॉक्स्ड चेतावनी)

Among patients who experienced an AST, one fatality (0.03%) occurred in a bivalirudin treated patient and one fatality (0.03%) in a heparin treated patient. (बिवालिरुडिन लेबल, चेतावनियां और सावधानियां)

Anticoagulant: rivaroxaban ↑ rivaroxaban Avoid concomitant use of rivaroxaban and ritonavir. (रिटोनाविर लेबल, दवाओं के इंटरैक्शन)

…Antipsychotics Haloperidol Decrease plasma concentrations by 70% Lurasidone Prevention or Management: Concomitant use is contraindicated (See CONTRAINDICATIONS ) Decrease exposure Oral Anticoagulants Prevention or Management: Perform prothrombin time daily or as frequently as necessary to establish and maintain the required dose of anticoagulant Warfarin Decrease… (रिफैम्पिसिन लेबल, दवाओं के इंटरैक्शन)

Avoid use of heparin after use of andexanet alfa for the reversal of direct Factor Xa inhibitors (apixaban and rivaroxaban). (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Heparin-induced thrombocytopenia (HIT): Initial therapy with warfarin sodium in HIT has resulted in cases of amputation and death. (वारफेरिन लेबल, चेतावनियां और सावधानियां)

Increased Bleeding Risk with Anticoagulants and Antiplatelet Agents: Some published studies with omega-3 fatty acids have demonstrated prolongation of bleeding time. (आइकोसापेंट एथिल लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Heparin: Allow sufficient time for heparin’s effect on activated partial thromboplastin time (aPTT) to decrease before initiating Argatroban Injection therapy. (आर्गाट्रोबैन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

- 7.1 Warfarin Concomitant administration of econazole and warfarin has resulted in enhancement of anticoagulant effect. (इकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Prothrombin times should be carefully monitored while patients are receiving azithromycin and oral anticoagulants concomitantly. (एज़िथ्रोमाइसिन लेबल, दवाओं के इंटरैक्शन)

Coumarin Anticoagulants: Obtain INR before VYTORIN initiation and monitor INR during VYTORIN dosage initiation or adjustment. (एज़ेटिमाइब और सिमवास्टेटिन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (एटोडोलैक लेबल, चेतावनियां)

• Proguanil may potentiate anticoagulant effect of warfarin and other coumarin-based anticoagulants. (एटोवाक्वोन और प्रोगुआनिल लेबल, दवाओं के इंटरैक्शन)

Anticoagulant : warfarin ↑ anticoagulants Warfarin concentrations may be increased when co-administered with Etravirine. (एट्राविरिन लेबल, दवाओं के इंटरैक्शन)

A number of drugs, including ethacrynic acid, have been shown to displace warfarin from plasma protein; a reduction in the usual anticoagulant dosage may be required in patients receiving both drugs. (एथाक्रिनिक एसिड लेबल, दवाओं के इंटरैक्शन)

Monitor patients for bleeding, including those receiving concomitant therapy with other drugs known to cause bleeding (e.g., anticoagulants, PDE3 inhibitors, NSAIDs, antiplatelet agents, selective serotonin reuptake inhibitors) [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] . (एनाग्रेलाइड लेबल, चेतावनियां और सावधानियां)

Patients receiving Epogen may require increased anticoagulation with heparin to prevent clotting of the extracorporeal circuit during hemodialysis. (एपोएटिन अल्फा लेबल, चेतावनियां और सावधानियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Concomitant Drug Class: Drug Name Effect Clinical Comment Anticoagulant: Warfarin ↑ or ↓ warfarin Monitor INR and adjust warfarin dosage if necessary. (एफाविरेंज़, लैमिवुडिन और टेनोफोविर लेबल, दवाओं के इंटरैक्शन)

Concomitant use of amoxicillin and oral anticoagulants may increase the prolongation of prothrombin time. (एमोक्सिसिलिन लेबल, दवाओं के इंटरैक्शन)

Concomitant use Amoxicillin and Clavulanate Potassium Extended Release Tablets and oral anticoagulants may increase the prolongation of prothrombin time. (एमोक्सिसिलिन और क्लैवुलैनेट लेबल, दवाओं के इंटरैक्शन)

…other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. (एम्लोडिपिन और वाल्सार्टन लेबल, दवाओं के इंटरैक्शन)

There have been reports of increased anticoagulant effects when erythromycin and oral anticoagulants were used concomitantly. (एरिथ्रोमाइसिन लेबल, दवाओं के इंटरैक्शन)

• Hemorrhage in patients taking warfarin: Regularly monitor INR in patients taking warfarin or other coumarin-derivative anticoagulants. (एर्लोटिनिब लेबल, चेतावनियां और सावधानियां)

Dicumarol Clinical Impact Allopurinol tablets prolongs the half-life of the anticoagulant, dicumarol. (एलोप्यूरिनॉल लेबल, दवाओं के इंटरैक्शन)

Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. (एल्टेप्लेज़ लेबल, चेतावनियां और सावधानियां)

• Injection site bleeding may occur in patients taking anticoagulants, such as warfarin or heparin. (एल्प्रोस्टाडिल लेबल, चेतावनियां और सावधानियां)

Anticoagulants: Direct Oral Anticoagulants (DOACs) apixaban rivaroxaban betrixaban dabigatran edoxaban ↑ apixaban Due to potentially increased bleeding risk, dosing recommendations for coadministration with GENVOYA depends on the apixaban dose. (एल्विटेग्राविर, कोबिसिस्टैट, एमट्रिसिटाबिन और टेनोफोविर लेबल, दवाओं के इंटरैक्शन)

Drug Interactions (Androgens) Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (एस्टरीफाइड एस्ट्रोजन और मिथाइलटेस्टोस्टेरोन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Increased Risk of Bleeding: Concomitant use of nonsteroidal anti-inflammatory drugs, aspirin, other antiplatelet drugs, warfarin and other anticoagulants may increase risk ( 5.7 , 7) (एस्सिटालोप्राम लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (ऑक्साप्रोज़िन लेबल, चेतावनियां और सावधानियां)

Hemorrhage : Increase frequency of monitoring in patients who are receiving oxaliplatin injection with fluorouracil/leucovorin and oral anticoagulants (5.9) (ऑक्सालिप्लैटिन लेबल, चेतावनियां और सावधानियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants including Warfarin Vitamin K absorption may be decreased with ORLISTAT. (ऑर्लिस्टैट लेबल, दवाओं के इंटरैक्शन)

Warfarin Some quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. (ओफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

Patients taking omega-3-acid ethyl esters capsules and an anticoagulant or other drug affecting coagulation (e.g., anti-platelet agents) should be monitored periodically. (ओमेगा-3-एसिड एथिल एस्टर लेबल, दवाओं के इंटरैक्शन)

Altered anticoagulant effects, including increased bleeding, have been reported when SNRIs or SSRIs are coadministered with warfarin [see Warnings and Precautions ( 5.16 )] . (ओलैंज़ापिन और फ्लुओक्सेटिन लेबल, दवाओं के इंटरैक्शन)

…Increasing Serum Potassium Concomitant use of olmesartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium. (ओल्मेसार्टन लेबल, दवाओं के इंटरैक्शन)

Warfarin (CYP1A2 and CYP3A4 Substrate) Through induction of CYP1A2 and CYP3A4, EQUETRO decreases the concentration of warfarin and decreases its anticoagulant effectiveness. (कार्बामाज़ेपिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants and Antiplatelet Drugs rivaroxaban cilostazol, coumarins, dabigatran Cilostazol: Concomitant administration of single doses of cilostazol 100 mg and ketoconazole 400 mg approximately doubled cilostazol concentrations and altered (increase/decrease) the concentrations of the active metabolites of cilostazol. (कीटोकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Patients receiving Ketoprofen Capsules, USP who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants, should be carefully monitored. (कीटोप्रोफेन लेबल, चेतावनियां और सावधानियां)

The concurrent use of ketorolac tromethamine and therapy that affects hemostasis, including prophylactic low-dose heparin (2500 to 5000 units q12h), warfarin and dextrans have not been studied extensively, but may also be associated with an increased risk of bleeding. (कीटोरोलैक लेबल, चेतावनियां और सावधानियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Closely monitor for adverse reactions of CYP2C9 substrates where minimal concentration changes may lead to serious adverse reactions when used concomitantly with XELODA (e.g., anticoagulants, antidiabetic drugs). (कैपेसिटाबिन लेबल, दवाओं के इंटरैक्शन)

Oral Anticoagulants: There is a risk of serious hemorrhage and significant elevations in INR and prothrombin time when clarithromycin is co-administered with warfarin. (क्लैरिथ्रोमाइसिन लेबल, चेतावनियां और सावधानियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

The anticoagulant effect of a single dose of warfarin (measured by prothrombin time) was not significantly changed by quinapril coadministration twice-daily. (क्विनाप्रिल लेबल, दवाओं के इंटरैक्शन)

By a mechanism that is not understood, quinidine potentiates the anticoagulatory action of warfarin , and the anticoagulant dosage may need to be reduced. (क्विनिडिन लेबल, दवाओं के इंटरैक्शन)

Warfarin and oral anticoagulants Cinchona alkaloids, including quinine, may have the potential to depress hepatic enzyme synthesis of vitamin K-dependent coagulation pathway proteins and may enhance the action of warfarin and other oral anticoagulants. (क्विनीन लेबल, दवाओं के इंटरैक्शन)

Griseofulvin decreases the activity of warfarin-type anticoagulants, so that patients receiving these drugs concomitantly may require dosage adjustment of the anticoagulant during and after griseofulvin therapy. (ग्रिसियोफुल्विन लेबल, दवाओं के इंटरैक्शन)

Warfarin Clincial Impact: GVOKE and GVOKE Vial Dx may increase the anticoagulant effect of warfarin. (ग्लूकागॉन लेबल, दवाओं के इंटरैक्शन)

Patients on oral warfarin anticoagulant therapy and zafirlukast should have their prothrombin times monitored closely and anticoagulant dose adjusted accordingly (see PRECAUTIONS, Drug Interactions ). (ज़ाफिरलुकास्ट लेबल, चेतावनियां)

एंटीकोएगुलेंट या एंटीप्लेटलेट दवाओं के साथ लेने पर जिन्कगो ब्लीडिंग का जोखिम बढ़ा सकता है। (NCCIH, Ginkgo)

Concomitant Anticoagulants – Caution should be exercised when warfarin is given in conjunction with LOPID. (जेमफाइब्रोज़िल लेबल, चेतावनियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

The following drug interactions were reported for metronidazole, a chemically-related nitroimidazole and may therefore occur with tinidazole: Warfarin and other oral coumarin anticoagulants: Anticoagulant dosage may need adjustment during and up to 8 days after tinidazole therapy ( 7.1 ) (टिनिडाज़ोल लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Because the tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (टेट्रासाइक्लिन लेबल, दवाओं के इंटरैक्शन)

Should serious bleeding that is not controlled by local pressure occur, discontinue any concomitant heparin or antiplatelet agents immediately and treat appropriately. (टेनेक्टेप्लेज़ लेबल, चेतावनियां और सावधानियां)

Frequent monitoring of INR and prothrombin time may be necessary in patients taking anticoagulants, especially at the initiation and termination of androgen therapy. (टेस्टोस्टेरोन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (टोल्मेटिन लेबल, चेतावनियां)

The effect of oral anticoagulants may be decreased when used concurrently with hydrochlorothiazide; dosage adjustments may be necessary. (ट्रायमटेरिन और हाइड्रोक्लोरोथायज़ाइड लेबल, दवाओं के इंटरैक्शन)

Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect. (ट्रायमसिनोलोन लेबल, दवाओं के इंटरैक्शन)

Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.5 ). (ट्रैज़ोडोन लेबल, चेतावनियां और सावधानियां)

Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin. (डाइक्लोक्सासिलिन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (डाइक्लोफेनाक लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (डाइक्लोफेनाक और मिसोप्रोस्टोल लेबल, चेतावनियां और सावधानियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (डाइफ्लुनिसाल लेबल, चेतावनियां)

The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproate therapy is instituted in patients taking anticoagulants. (डाइवैल्प्रोएक्स (वैल्प्रोएट) लेबल, दवाओं के इंटरैक्शन)

It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram, since disulfiram may prolong prothrombin time. (डाइसल्फिरम लेबल, दवाओं के इंटरैक्शन)

Anticoagulants : Direct Oral Anticoagulants (DOACs) apixaban ↑ apixaban Due to potentially increased bleeding risk, dosing recommendations for co-administration of apixaban with PREZISTA/ritonavir depend on the apixaban dose. (डारुनाविर लेबल, दवाओं के इंटरैक्शन)

Anticoagulants: Direct Oral Anticoagulants (DOACs) apixaban ↑ apixaban Due to potentially increased bleeding risk, dosing recommendations for co-administration of apixaban with PREZCOBIX or PREZCOBIX PED depend on the apixaban dose. (डारुनाविर और कोबिसिस्टैट लेबल, दवाओं के इंटरैक्शन)

Use caution if used concomitantly with medications that inhibit platelet function or anticoagulants. (डासाटिनिब लेबल, चेतावनियां और सावधानियां)

Concomitant use of antiplatelet drugs and anticoagulants may increase this risk. (डुलोक्सेटिन लेबल, चेतावनियां और सावधानियां)

(‎ 5.3 ) • Venous and Arterial Thromboembolism: Risk increased; consider anticoagulant prophylaxis and monitor for evidence of thromboembolism. (डेक्सामेथासोन लेबल, चेतावनियां और सावधानियां)

The risk of GI hemorrhage may be increased when administering Exjade in combination with drugs that have ulcerogenic or hemorrhagic potential, such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, oral bisphosphonates, or anticoagulants. (डेफेरासिरोक्स लेबल, चेतावनियां और सावधानियां)

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (डेमेक्लोसाइक्लिन लेबल, दवाओं के इंटरैक्शन)

• Increased Risk of Bleeding: Concomitant use of aspirin, NSAIDs, other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.4 ). (डेसवेनलाफैक्सिन लेबल, चेतावनियां और सावधानियां)

Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (डॉक्सीसाइक्लिन लेबल, दवाओं के इंटरैक्शन)

Concomitant medications were grouped as ACE inhibitors, oral anticoagulants, calcium channel blockers, beta blockers, cardiac glycosides, inducers of CYP3A4, substrates and inhibitors of CYP3A4, substrates and inhibitors of P-glycoprotein, nitrates, sulphonylureas, loop diuretics, potassium sparing diuretics, thiazide diuretics, substrates and inhibitors of tubular… (डोफेटिलाइड लेबल, दवाओं के इंटरैक्शन)

Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin-II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDS. (ड्रोस्पिरेनोन और एथिनिल एस्ट्राडियोल लेबल, चेतावनियां और सावधानियां)

Intravenous nitroglycerin administered to heparinized patients may result in a decrease of the partial thromboplastin time with subsequent rebound effect upon discontinuation of nitroglycerin. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants Nintedanib is a VEGFR inhibitor and may increase the risk of bleeding. (निंटेडानिब लेबल, दवाओं के इंटरैक्शन)

Antithrombotics Coumarins: There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. (निफेडिपिन लेबल, दवाओं के इंटरैक्शन)

Caution should be observed when niacin extended-release tablets are administered concomitantly with anticoagulants; platelet counts should be monitored closely in such patients. (नियासिन लेबल, चेतावनियां और सावधानियां)

Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability. (नियोमाइसिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants warfarin ↑↓ warfarin Closely monitor international normalized ratio (INR) if co-administration with warfarin is necessary. rivaroxaban ↑ rivaroxaban Increased bleeding risk with rivaroxaban. (निर्माट्रेल्विर और रिटोनाविर लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (नेप्रोक्सेन लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (नेप्रोक्सेन और एसोमेप्राज़ोल लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (नैबुमेटोन लेबल, चेतावनियां)

Monitor coagulation parameters in patients receiving Piperacillin and Tazobactam for Injection and Sodium Chloride Injection and heparin or oral anticoagulants. (पाइपेरासिलिन और टैज़ोबैक्टम लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (पाइरोक्सिकैम लेबल, चेतावनियां और सावधानियां)

DRUG INTERACTIONS Bleeding has been reported in patients treated with pentoxifylline extended-release tablets with or without concomitant NSAIDs, anticoagulants, or platelet aggregation inhibitors. (पेंटोक्सिफाइलिन लेबल, दवाओं के इंटरैक्शन)

Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia. (पेरिंडोप्रिल लेबल, दवाओं के इंटरैक्शन)

Chronic oral acetaminophen use at a dose of 4,000 mg/day has been shown to cause an increase in international normalized ratio (INR) in some patients who have been stabilized on sodium warfarin as an anticoagulant. (पैरासिटामोल लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk. (पैरोक्सेटिन लेबल, चेतावनियां और सावधानियां)

In Trial 2, where anticoagulant therapies were mandated, thromboembolic events occurred in 8.0% of patients treated with POMALYST and low dose-dexamethasone (Low-dose Dex), and 3.3% of patients treated with high-dose dexamethasone. (पोमालिडोमाइड लेबल, चेतावनियां और सावधानियां)

Anticoagulant agents: May enhance or diminish anticoagulant effects. (प्रेडनिसोन लेबल, दवाओं के इंटरैक्शन)

Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect. (प्रेडनिसोलोन लेबल, दवाओं के इंटरैक्शन)

Drug Interactions Anticoagulants (oral) : Due to the potential inhibition of vitamin K activity by propylthiouracil, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. (प्रोपाइलथायोयूरेसिल लेबल, दवाओं के इंटरैक्शन)

Anticoagulants Phytonadione injectable emulsion may induce temporary resistance to prothrombin-depressing anticoagulants, especially when larger doses of phytonadione injectable emulsion are used. (फाइटोमेनाडायोन (विटामिन K1) लेबल, दवाओं के इंटरैक्शन)

Risk of Bleeding: Use with caution in patients with bleeding diatheses, thrombocytopenia, or anticoagulant use. (फुल्वेस्ट्रेंट लेबल, चेतावनियां और सावधानियां)

…Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D Drugs whose level is decreased by phenytoin Anticoagulants Apixaban, dabigatran, edoxaban, rivaroxaban Antiepileptic drugs The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable. (फेनिटोइन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (फेनोप्रोफेन लेबल, चेतावनियां और सावधानियां)

Increased Bleeding Risk with Coumarin Anticoagulants Exercise caution when co-administering anticoagulants with fenofibric acid delayed-release capsules because of the potentiation of coumarin-type anticoagulant effects in prolonging the prothrombin time/International Normalized Ratio (PT/INR). (फेनोफाइब्रिक एसिड लेबल, चेतावनियां और सावधानियां)

Increased Bleeding Risk with Coumarin Anticoagulants Exercise caution when co-administering anticoagulants with fenofibrate capsules because of the potentiation of coumarin-type anticoagulant effects in prolonging the prothrombin time/International Normalized Ratio (PT/INR). (फेनोफाइब्रेट लेबल, चेतावनियां और सावधानियां)

Phenobarbital may decrease the effect of anticoagulants, and necessitate larger doses of the anticoagulant for optimal effect. (फेनोबार्बिटोन, हायोसायमिन, एट्रोपिन और स्कोपोलामाइन (हायोसिन) लेबल, चेतावनियां)

…Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D Drugs whose level is decreased by phenytoin Anticoagulants Apixaban, dabigatran, edoxaban, rivaroxaban Antiepileptic drugs The effect of phenytoin on phenobarbital, valproic acid and sodium valproate serum levels is unpredictable. (फॉस्फेनिटोइन लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking, use of alcohol, older age, and poor general health status. (फ्लर्बिप्रोफेन लेबल, चेतावनियां और सावधानियां)

Altered anticoagulant effects, including increased bleeding, have been reported when SNRIs or SSRIs are coadministered with warfarin. (फ्लुओक्सेटिन लेबल, दवाओं के इंटरैक्शन)

Closely monitor patients receiving concomitant coumarin-derivative anticoagulants such as warfarin for INR or prothrombin time in order to adjust the anticoagulant dose accordingly [see Drug Interactions (7) ]. (फ्लुओरोयूरेसिल लेबल, चेतावनियां और सावधानियां)

Coumarin-type anticoagulants Prothrombin time may be increased in patients receiving concomitant fluconazole and coumarin-type anticoagulants. (फ्लुकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Therefore close monitoring of prothrombin time is recommended and adjustment of the anticoagulant dose may be necessary when Eulexin ® capsules are administered concomitantly with warfarin. (फ्लुटामाइड लेबल, दवाओं के इंटरैक्शन)

Oral anticoagulants — decreased prothrombin time response. (फ्लुड्रोकॉर्टिसोन लेबल, दवाओं के इंटरैक्शन)

Thus patients receiving oral anticoagulants and Fluvoxamine Maleate Tablets should have their prothrombin time monitored and their anticoagulant dose adjusted accordingly. (फ्लुवोक्सामिन लेबल, चेतावनियां और सावधानियां)

Closely monitor the Prothrombin Time (PT) and International Normalized Ratio (INR), and adjust the anticoagulant dose as needed. (बाइकैलुटामाइड लेबल, चेतावनियां और सावधानियां)

Metronidazole has been reported to potentiate the anticoagulant effect of warfarin, and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. (बिस्मथ सबसाइट्रेट, मेट्रोनिडाज़ोल और टेट्रासाइक्लिन लेबल, चेतावनियां और सावधानियां)

Concomitant administration of betaxolol with the oral anticoagulant warfarin has been shown not to potentiate the anticoagulant effect of warfarin. (बीटाक्सोलोल लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Warfarin : Mercaptopurine tablets may decrease the anticoagulant effect. (मर्कैप्टोप्यूरिन लेबल, दवाओं के इंटरैक्शन)

Warfarin: Miconazole may enhance anticoagulant effect. (माइकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

DRUG INTERACTIONS Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants. (मिथाइलटेस्टोस्टेरोन लेबल, दवाओं के इंटरैक्शन)

Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect. (मिथाइलप्रेडनिसोलोन लेबल, दवाओं के इंटरैक्शन)

Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. (मिनोसाइक्लिन लेबल, दवाओं के इंटरैक्शन)

Mifepristone should be used with caution in women who have hemorrhagic disorders or are receiving concurrent anticoagulant therapy. (मिफेप्रिस्टोन लेबल, चेतावनियां और सावधानियां)

Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anticoagulants may add to this risk. (मिल्नासिप्रान लेबल, चेतावनियां और सावधानियां)

Anticoagulants Metolazone, as well as other thiazide-like diuretics, may affect the hypoprothrombinemic response to anticoagulants; dosage adjustments may be necessary. (मेटोलाज़ोन लेबल, दवाओं के इंटरैक्शन)

Warfarin and Other Oral Anticoagulants : LIKMEZ can potentiate the anticoagulant effect. (मेट्रोनिडाज़ोल लेबल, दवाओं के इंटरैक्शन)

Drug Interactions Anticoagulants (oral): Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. β-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers… (मेथिमाज़ोल लेबल, दवाओं के इंटरैक्शन)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, anti-platelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs), smoking, use of alcohol, older age, and poor general health status. (मेफेनामिक एसिड लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (मेलोक्सिकैम लेबल, चेतावनियां और सावधानियां)

Interacting Drug Interaction Warfarin Anticoagulant effect of warfarin may be enhanced. (मॉक्सीफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

…Within Class Antiarrhythmics Disopyramide, mexiletine, quinidine, tocainide Antibiotics Chloramphenicol, clarithromycin, dapsone, doxycycline; Fluoroquinolones (such as ciprofloxacin) Oral Anticoagulants Warfarin Anticonvulsants Phenytoin Antimalarials Quinine Azole Antifungals Fluconazole, itraconazole, ketoconazole Antipsychotics Haloperidol Barbiturates Phenobarbital… (रिफापेंटिन लेबल, दवाओं के इंटरैक्शन)

Oral Anticoagulants Liothyronine sodium increases the response to oral anticoagulant therapy. (लियोथायरोनिन लेबल, दवाओं के इंटरैक्शन)

A significantly increased risk of DVT (7.4%) and of PE (3.7%) occurred in patients with MM after at least one prior therapy who were treated with REVLIMID and dexamethasone therapy compared to patients treated in the placebo and dexamethasone group (3.1% and 0.9%) in clinical trials with varying use of anticoagulant therapies. (लेनालिडोमाइड लेबल, चेतावनियां और सावधानियां)

Oral Anticoagulants Levothyroxine increases the response to oral anticoagulant therapy. (लेवोथायरोक्सिन लेबल, दवाओं के इंटरैक्शन)

Drug Interactions Oral Anticoagulants — Thyroid hormones appear to increase catabolism of vitamin K-dependent clotting factors. (लेवोथायरोक्सिन और लियोथायरोनिन लेबल, दवाओं के इंटरैक्शन)

…Skyla with caution after careful assessment if any of the following conditions exist, and consider removal of the system if any of them arise during use: • Coagulopathy or use of anticoagulants • Migraine, focal migraine with asymmetrical visual loss or other symptoms indicating transient cerebral ischemia • Exceptionally severe headache • Marked increase of… (लेवोनॉरजेस्ट्रेल लेबल, चेतावनियां और सावधानियां)

Increased Risk of Bleeding : Concomitant use of NSAIDs, aspirin, other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.5 ). (लेवोमिल्नासिप्रान लेबल, चेतावनियां और सावधानियां)

Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. (लोवास्टेटिन लेबल, दवाओं के इंटरैक्शन)

…other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. (वाल्सार्टन लेबल, दवाओं के इंटरैक्शन)

…other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. (वाल्सार्टन और हाइड्रोक्लोरोथायज़ाइड लेबल, दवाओं के इंटरैक्शन)

विटामिन E प्लेटलेट के आपस में जुड़ने (एग्रीगेशन) और विटामिन K पर निर्भर क्लॉटिंग को रोक सकता है, जिससे एंटीकोएगुलेंट और एंटीप्लेटलेट दवाओं के साथ ब्लीडिंग का जोखिम बढ़ता है। (NIH Office of Dietary Supplements, Vitamin E)

Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (विलाज़ोडोन लेबल, चेतावनियां और सावधानियां)

Concomitant use of aspirin, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), warfarin, and other anticoagulants may add to this risk. (वेनलाफैक्सिन लेबल, चेतावनियां और सावधानियां)

The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproate therapy is instituted in patients taking anticoagulants. (वैल्प्रोइक एसिड लेबल, दवाओं के इंटरैक्शन)

Warfarin (CYP2C9 Inhibition) Other Oral Coumarin Anticoagulants (CYP2C9/3A4 Inhibition) Prothrombin Time Significantly Increased Not Studied In Vivo or In Vitro for other Oral Coumarin Anticoagulants, but Drug Plasma Exposure Likely to be Increased If patients receiving coumarin preparations are treated simultaneously with voriconazole, the prothrombin time or… (वोरिकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and other anticoagulants may add to this risk. (वोर्टियोक्सेटिन लेबल, चेतावनियां और सावधानियां)

Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.3 ) (सर्ट्रालिन लेबल, चेतावनियां और सावधानियां)

Drug Interactions Administration of a sulfonamide may increase the effect of oral anticoagulants and methotrexate, probably by displacement of these drugs from binding sites on plasma albumin. (सल्फाडायज़िन लेबल, दवाओं के इंटरैक्शन)

It has been reported that sulfamethoxazole and trimethoprim may prolong the prothrombin time in patients who are receiving the anticoagulant warfarin. (सल्फामेथॉक्साज़ोल और ट्राइमेथोप्रिम लेबल, दवाओं के इंटरैक्शन)

Monitor anticoagulant activity closely in patients receiving warfarin or other coumarins. (साइक्लोफॉस्फामाइड लेबल, दवाओं के इंटरैक्शन)

Though resolution has occurred after reduction or discontinuation of cyclosporine and 1) administration of streptokinase and heparin or 2) plasmapheresis, this appears to depend upon early detection with Indium 111 labeled platelet scans (see ADVERSE REACTIONS) . (साइक्लोस्पोरिन लेबल, चेतावनियां)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (साल्सालेट लेबल, चेतावनियां)

Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk. (सिटालोप्राम लेबल, चेतावनियां और सावधानियां)

Anti-coagulant drugs Use with caution (Increase in anticoagulant effect) The risk may vary with the underlying infection, age and general status of the patient so that the contribution of ciprofloxacin to the increase in INR (international normalized ratio) is difficult to assess. (सिप्रोफ्लॉक्सासिन लेबल, दवाओं के इंटरैक्शन)

Coumarin Anticoagulants: Obtain INR before ZOCOR initiation and monitor INR during ZOCOR dosage initiation or adjustment. (सिमवास्टेटिन लेबल, दवाओं के इंटरैक्शन)

Drug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination… (सिमेटिडीन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

In addition, the combination of heparin and sildenafil had an additive effect on bleeding time in the anesthetized rabbit, but this interaction has not been studied in humans. (सिल्डेनाफिल लेबल, चेतावनियां और सावधानियां)

In vitro experiments demonstrated additional aPTT and PT(INR) prolongations for sugammadex in combination with vitamin K antagonists, unfractionated heparin, low molecular weight heparinoids, rivaroxaban, and dabigatran up to ~25% and ~50% at C max levels of sugammadex corresponding to 4 mg/kg and 16 mg/kg doses, respectively. (सुगैमाडेक्स लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk for gastrointestinal bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (सुमाट्रिप्टान और नेप्रोक्सेन लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (सुलिंडैक लेबल, चेतावनियां)

Those at risk include patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (सेफाज़ोलिन लेबल, चेतावनियां और सावधानियां)

Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antimicrobial therapy, and patients previously stabilized on anticoagulant therapy. (सेफिक्सिम लेबल, चेतावनियां और सावधानियां)

Those at risk include patients with renal or hepatic impairment, or poor nutritional state, as well as patients receiving a protracted course of antibacterial therapy, and patients receiving anticoagulant therapy. (सेफैलेक्सिन लेबल, चेतावनियां और सावधानियां)

Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (सेलेकॉक्सिब लेबल, चेतावनियां और सावधानियां)

Anticoagulants: dabigatran etexilate ↑ dabigatran Clinical monitoring of dabigatran is recommended when coadministered with VOSEVI. (सोफोसबुविर और वेल्पाटासविर लेबल, दवाओं के इंटरैक्शन)

Examples of drugs that can increase potassium include: ACE inhibitors angiotensin receptor blockers aldosterone blockers non-steroidal anti-inflammatory drugs (NSAIDs) heparin and low molecular weight heparin trimethoprim 7.2 Lithium Like other diuretics, spironolactone oral suspension reduces the renal clearance of lithium, thus increasing the risk of lithium… (स्पिरोनोलैक्टोन लेबल, दवाओं के इंटरैक्शन)

…potassium-sparing diuretics • ACE inhibitors • angiotensin II receptor antagonists • aldosterone blockers • non-steroidal anti-inflammatory drugs (NSAIDs), e.g., indomethacin • heparin and low molecular weight heparin • other drugs or conditions known to cause hyperkalemia • potassium supplements • diet rich in potassium • salt substitutes containing potassium Spironolactone… (स्पिरोनोलैक्टोन और हाइड्रोक्लोरोथायज़ाइड लेबल, चेतावनियां)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Intervention: Monitor coagulation indices in patients receiving ALKINDI SPRINKLE and concomitant warfarin to maintain the desired anticoagulant effect. (हाइड्रोकॉर्टिसोन लेबल, दवाओं के इंटरैक्शन)

Platelet Inhibitors Drugs such as acetylsalicylic acid, dextran, phenylbutazone, ibuprofen, indomethacin, dipyridamole, hydroxychloroquine and others that interfere with platelet-aggregation reactions (the main hemostatic defense of heparinized patients) may induce bleeding and should be used with caution in patients receiving heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Patients who require anticoagulation should receive low-molecular weight or standard heparin and not warfarin. (इमैटिनिब लेबल, दवाओं के इंटरैक्शन)

Use with Warfarin: IMURAN may inhibit the anticoagulant effect of warfarin. (एज़ाथियोप्रिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Oral Anticoagulants Although clinical studies have not established a cause and effect relationship, physicians should be aware that variable effects on blood coagulation have been reported very rarely in patients receiving oral anticoagulants and chlordiazepoxide hydrochloride, a component of Librax. (क्लोरडायज़ेपॉक्साइड और क्लिडिनियम लेबल, दवाओं के इंटरैक्शन)

Chlorpromazine diminishes the effect of oral anticoagulants. (क्लोरप्रोमाज़िन लेबल, सावधानियां)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Phenothiazines may diminish the effect of oral anticoagulants. (ट्राइफ्लुओपेराज़िन लेबल, सावधानियां)

The anticoagulant effect of warfarin was not significantly changed by trandolapril. (ट्रैंडोलाप्रिल लेबल, दवाओं के इंटरैक्शन)

Therapy consisting of prompt removal of the source of procoagulant material, replacement of depleted clotting factors and, in some cases, anti-coagulation with heparin should be instituted promptly. (डाइनोप्रोस्टोन लेबल, चेतावनियां और सावधानियां)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (डोब्यूटामिन लेबल, दवाओं के इंटरैक्शन)

More patients experienced clinically significant INR elevations (≥5) usually within 1 week after starting dronedarone versus placebo in patients taking oral anticoagulants in ATHENA. (ड्रोनेडेरोन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Phenothiazines can diminish the effect of oral anticoagulants. (प्रोक्लोरपेराज़िन लेबल, सावधानियां)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulant: Warfarin Concentrations of warfarin may be affected. (फोसएम्प्रेनाविर लेबल, दवाओं के इंटरैक्शन)

In a pharmacokinetic interaction study with warfarin, bioavailability parameters, the degree of protein binding, and the anticoagulant effect (measured by prothrombin time) of warfarin were not significantly changed. (फोसिनोप्रिल लेबल, दवाओं के इंटरैक्शन)

Interaction studies with warfarin have failed to identify any clinically important effects of fosinopril on the serum concentration or clinical effects of the anticoagulant. (फोसिनोप्रिल और हाइड्रोक्लोरोथायज़ाइड लेबल, दवाओं के इंटरैक्शन)

Consequently, interactions with other drugs which are highly protein bound (e.g., anticoagulants ) would not be expected. (फ्लेकेनाइड लेबल, दवाओं के इंटरैक्शन)

Anticoagulants: Direct Oral Anticoagulants (DOACs) rivaroxaban dabigatran edoxaban ↑ DOAC Refer to the DOAC prescribing information for concomitant administration with moderate CYP3A inhibitors and/or P-gp inhibitors. (बिक्टेग्राविर, एमट्रिसिटाबिन और टेनोफोविर एलाफेनामाइड लेबल, दवाओं के इंटरैक्शन)

Interaction studies with warfarin and acenocoumarol have failed to identify any clinically important effects of benazepril on the serum concentrations or clinical effects of these anticoagulants. (बेनाज़ेप्रिल और हाइड्रोक्लोरोथायज़ाइड लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

ओमेगा-3 सप्लीमेंट ब्लीडिंग टाइम को हल्का-सा बढ़ा सकते हैं; वारफेरिन जैसे एंटीकोएगुलेंट के साथ इस संयोजन में निगरानी उचित है, हालांकि चिकित्सकीय रूप से महत्वपूर्ण ब्लीडिंग लगातार एक जैसी नहीं दिखाई गई है। (NIH Office of Dietary Supplements, Omega-3 Fatty Acids)

…been observed in limited experience with patients in whom milrinone was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements. (मिलरिनोन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

In a large compassionate use program mexiletine has been used concurrently with commonly employed antianginal, antihypertensive, and anticoagulant drugs without observed interactions. (मेक्सिलेटिन लेबल, दवाओं के इंटरैक्शन)

Arterial injection of heparin at the site of injury, followed by systemic anticoagulation. (मेथोहेक्सिटल लेबल, चेतावनियां)

Nevertheless, the effects of mefloquine on travelers receiving concomitant medications, particularly diabetics or patients using anticoagulants, should be checked before departure. (मेफ्लोक्वीन लेबल, दवाओं के इंटरैक्शन)

Oral Anticoagulants: Interaction studies with warfarin failed to identify any clinically important effect on the serum concentrations of the anticoagulant or on its anticoagulant effect. (मोएक्सिप्रिल लेबल, दवाओं के इंटरैक्शन)

लहसुन के सप्लीमेंट वारफेरिन जैसे एंटीकोएगुलेंट के साथ ब्लीडिंग का जोखिम बढ़ा सकते हैं। (NCCIH, Garlic)

Anticoagulants: Direct Oral Anticoagulants (DOACs) rivaroxaban dabigatran edoxaban ↑ DOAC Refer to the DOAC prescribing information for concomitant administration with moderate CYP3A inhibitors and/or P-gp inhibitors. (लेनाकैपाविर लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants: warfarin, rivaroxaban ↑↓ warfarin ↑ rivaroxaban Concentrations of warfarin may be affected. (लोपिनाविर और रिटोनाविर लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Other Interactions Digitalis, tetracyclines, nicotine, or antihistamines, or intravenous nitroglycerin may partially counteract the anticoagulant action of heparin sodium. (हेपरिन लेबल, दवाओं के इंटरैक्शन)

Warfarin In a study conducted in 16 male volunteers, anastrozole did not alter the exposure (as measured by C max and AUC) and anticoagulant activity (as measured by prothrombin time, activated partial thromboplastin time, and thrombin time) of both R- and S-warfarin. (एनास्ट्रोज़ोल लेबल, दवाओं के इंटरैक्शन)

Investigations into the effect of acitretin on the protein binding of anticoagulants of the coumarin type (warfarin) revealed no interaction. (एसिट्रेटिन लेबल, दवाओं के इंटरैक्शन)

Warfarin A clinical study has shown that fesoterodine 8 mg once daily has no significant effect on the pharmacokinetics or the anticoagulant activity (PT/INR) of warfarin 25 mg. (फेसोटेरोडिन लेबल, दवाओं के इंटरैक्शन)

Anticoagulants Interaction studies in humans have shown bumetanide to have no effect on warfarin metabolism or on plasma prothrombin activity. (बुमेटेनाइड लेबल, दवाओं के इंटरैक्शन)