पैक्लिटैक्सेल के इंटरैक्शन

Use of REYATAZ without ritonavir is not recommended when coadministered with drugs highly dependent on CYP2C8 with narrow therapeutic indices (eg, paclitaxel, repaglinide). (एटाज़ानाविर लेबल, दवाओं के इंटरैक्शन)

…within at least 72 hours of treatment with ketoconazole Antineoplastics irinotecan dasatinib, lapatinib, nilotinib bortezomib, busulphan, docetaxel, erlotinib, imatinib, ixabepilone, paclitaxel, trimetrexate, vinca alkaloids Irinotecan: The potential increase in plasma concentrations of irinotecan when coadministered with ketoconazole tablets may increase the risk… (कीटोकोनाज़ोल लेबल, दवाओं के इंटरैक्शन)

Pneumonitis Pneumonitis, including some cases that were fatal, occurred in 4% of patients receiving protein bound paclitaxel in combination with gemcitabine. (पैक्लिटैक्सेल लेबल, चेतावनियां और सावधानियां)

AC Anthracycline (doxorubicin) and cyclophosphamide. → Paclitaxel+Trastuzumab 3.2% (64/2000) Includes 1 patient with fatal cardiomyopathy and 1 patient with sudden death without documented etiology. (ट्रैस्टुज़ुमैब लेबल, चेतावनियां और सावधानियां)

Patients who have previously experienced a hypersensitivity reaction to paclitaxel may develop a hypersensitivity reaction to docetaxel that may include severe or fatal reactions such as anaphylaxis. (डोसेटैक्सेल लेबल, चेतावनियां और सावधानियां)

• NEXAVAR in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer [see Warnings and Precautions ( 5.8 )] . (सोराफेनिब लेबल, निषेध (कॉन्ट्राइंडिकेशन))

…patients with NSCLC, resume treatment if recommended at permanently reduced doses for both weekly protein-bound paclitaxel for Injectable Suspension (albumin-bound) and every-3-week carboplatin after ANC recovers to at least 1,500 cells/mm 3 and platelet count of at least 100,000 cells/mm 3 on Day 1 or to an ANC of at least 500 cells/mm 3 and platelet count of… (पैक्लिटैक्सेल लेबल, चेतावनियां और सावधानियां)

(C) CYP2C8 Substrates Gemfibrozil is a strong inhibitor of CYP2C8 and may increase exposure of drugs mainly metabolized by CYP2C8 (e.g., dabrafenib, enzalutamide, loperamide, montelukast, paclitaxel, pioglitazone, rosiglitazone). (जेमफाइब्रोज़िल लेबल, दवाओं के इंटरैक्शन)

In patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased. (टेरिफ्लुनोमाइड लेबल, दवाओं के इंटरैक्शन)

Agents Metabolized by CYP2C8 Deferasirox inhibits CYP2C8 resulting in an increase in CYP2C8 substrate (e.g., repaglinide and paclitaxel) concentration when these drugs are coadministered. (डेफेरासिरोक्स लेबल, दवाओं के इंटरैक्शन)

Paclitaxel Paclitaxel, when given prior to doxorubicin hydrochloride, increases the plasma-concentrations of doxorubicin and its metabolites. (डॉक्सोरूबिसिन लेबल, दवाओं के इंटरैक्शन)

Table 3: Drugs Affected by Phenytoin Interacting Agent Examples Drugs whose efficacy is impaired by phenytoin Azoles Fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole Antineoplastic agents Irinotecan, paclitaxel, teniposide Delavirdine Phenytoin can substantially reduce the concentrations of delavirdine. (फेनिटोइन लेबल, दवाओं के इंटरैक्शन)

Table 7: Drugs Affected by Phenytoin Interacting Agent Examples Drugs whose efficacy is impaired by phenytoin Azoles Fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole Antineoplastic agents Irinotecan, paclitaxel, teniposide Delavirdine Phenytoin can substantially reduce the concentrations of delavirdine. (फॉस्फेनिटोइन लेबल, दवाओं के इंटरैक्शन)

In patients taking ARAVA, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased. (लेफ्लुनोमाइड लेबल, दवाओं के इंटरैक्शन)

Paclitaxel : In cancer patients receiving TYKERB and paclitaxel (CYP2C8 and P-gp substrate), 24-hour systemic exposure (AUC) of paclitaxel was increased 23%. (लैपाटिनिब लेबल, दवाओं के इंटरैक्शन)

Concomitant administration of R verapamil can decrease the clearance of paclitaxel. (वेरापामिल लेबल, दवाओं के इंटरैक्शन)

…that Potentiate Cyclophosphamide Toxicities Toxicity Drugs Increased hematotoxicity and/or immunosuppression ● ACE inhibitors: ACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ●… (साइक्लोफॉस्फामाइड लेबल, दवाओं के इंटरैक्शन)

Etoposide, vinorelbine, paclitaxel, and docetaxel No dosage adjustment needed. (एप्रेपिटेंट लेबल, दवाओं के इंटरैक्शन)

Etoposide, vinorelbine, paclitaxel, and docetaxel No dosage adjustment needed. (फोसाप्रेपिटेंट लेबल, दवाओं के इंटरैक्शन)

Effects of VEGZELMA on Other Drugs No clinically meaningful effect on the pharmacokinetics of irinotecan or its active metabolite SN38, interferon alfa, carboplatin or paclitaxel was observed when bevacizumab was administered in combination with these drugs; however, 3 of the 8 patients receiving bevacizumab with paclitaxel and carboplatin had lower paclitaxel… (बेवासिज़ुमैब लेबल, दवाओं के इंटरैक्शन)