ट्रेप्रोस्टिनिल के इंटरैक्शन

Ketorolac tromethamine is contraindicated in labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine contractions, thus increasing the risk of uterine hemorrhage. (कीटोरोलैक लेबल, निषेध (कॉन्ट्राइंडिकेशन))

…fatal, anaphylactic reactions to NSAIDs have been reported in such patients [see Warnings and Precautions (5.8 , 5.9) ] • Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to diclofenac sodium and misoprostol, other prostaglandins, or any components of the drug product [see Warnings and Precautions (5.8 , 5.10) ] • Pregnancy ( 4 ) (डाइक्लोफेनाक और मिसोप्रोस्टोल लेबल, निषेध (कॉन्ट्राइंडिकेशन))

The combined use of two or more prostaglandins, or prostaglandin analogs including XELPROS is not recommended. (लैटानोप्रोस्ट लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (आइबुप्रोफेन लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (आइबुप्रोफेन और फैमोटिडीन लेबल, चेतावनियां और सावधानियां)

Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators. (आइसोसॉर्बाइड डाइनाइट्रेट लेबल, दवाओं के इंटरैक्शन)

The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. (आइसोसॉर्बाइड मोनोनाइट्रेट लेबल, दवाओं के इंटरैक्शन)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (इंडोमेथासिन लेबल, चेतावनियां और सावधानियां)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (एटेनोलोल लेबल, दवाओं के इंटरैक्शन)

Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers. (एटेनोलोल और क्लोरथैलिडोन लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (एटोडोलैक लेबल, चेतावनियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Hypotension Adenosine injection is a potent peripheral vasodilator and can induce significant hypotension. (एडेनोसिन लेबल, चेतावनियां और सावधानियां)

Additional reductions in blood pressure may occur when VELETRI is administered with diuretics, antihypertensive agents, or other vasodilators. (एपोप्रोस्टेनोल लेबल, दवाओं के इंटरैक्शन)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis. (एम्लोडिपिन और वाल्सार्टन लेबल, चेतावनियां और सावधानियां)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (एवानाफिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (ऑक्साप्रोज़िन लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

A second form of renal toxicity has been seen in patients with conditions leading to a reduction in renal blood flow or blood volume, where renal prostaglandins have a supportive role in the maintenance of renal blood flow. (कीटोप्रोफेन लेबल, चेतावनियां और सावधानियां)

Valvular Stenosis There is concern, on theoretical grounds, that patients with aortic stenosis might be at particular risk of decreased coronary perfusion when treated with vasodilators because they do not develop as much afterload reduction as others. (कैप्टोप्रिल लेबल, सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Co-administration of a cytochrome P450 (CYP) 2C8 enzyme inhibitor (e.g., gemfibrozil) may increase exposure (both C max and AUC) to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (टैडालाफिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (टोल्मेटिन लेबल, चेतावनियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (डाइक्लोफेनाक लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (डाइफ्लुनिसाल लेबल, चेतावनियां)

• Co-administration with Other Vasodilators or Negative Chronotropic Agents : Use with caution due to additive pharmacodynamic effects. (डेक्समेडेटोमिडिन लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Nifedipine is a vasodilator, and co-administration of other drugs affecting blood pressure may result in pharmacodynamic interactions. (निफेडिपिन लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (नेप्रोक्सेन लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (नेप्रोक्सेन और एसोमेप्राज़ोल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (नैबुमेटोन लेबल, चेतावनियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (पाइरोक्सिकैम लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (पैरासिटामोल और आइबुप्रोफेन लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (फेनोप्रोफेन लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Indomethacin Coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. (फ्यूरोसेमाइड लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (फ्लर्बिप्रोफेन लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Caution should be exercised when methylergonovine maleate is used concurrently with other vasoconstrictors, ergot alkaloids, or prostaglandins. (मिथाइलएर्गोमेट्रिन लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (मेफेनामिक एसिड लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (मेलोक्सिकैम लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

The pharmacokinetics of R- and S- warfarin and the international normalized ratio (INR) in healthy subjects given a single 25 mg dose of warfarin were unaffected by continuous subcutaneous infusion of treprostinil at an infusion rate of 10 ng/kg/min. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. (वार्डेनाफिल लेबल, चेतावनियां और सावधानियां)

Antihypertensive Agents Verapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers) will usually have an additive effect on lowering blood pressure. (वेरापामिल लेबल, दवाओं के इंटरैक्शन)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (साल्सालेट लेबल, चेतावनियां)

Blood Pressure Decreases Patients with left ventricular outflow obstruction (e.g., aortic stenosis, idiopathic hypertrophic subaortic stenosis) and those with severely impaired autonomic control of blood pressure can be sensitive to the actions of vasodilators, including SILDENAFIL ORAL FILM. (सिल्डेनाफिल लेबल, चेतावनियां और सावधानियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (सुमाट्रिप्टान और नेप्रोक्सेन लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion.In these patients, administration of a non-steroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. (सुलिंडैक लेबल, चेतावनियां)

Co-administration of a CYP2C8 enzyme inducer (e.g., rifampin) may decrease exposure to treprostinil. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (सेलेकॉक्सिब लेबल, चेतावनियां और सावधानियां)

Renal Toxicity and Hyperkalemia Renal Toxicity Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. (हाइड्रोकोडोन और आइबुप्रोफेन लेबल, चेतावनियां)

Phosphodiesterase-5 (PDE5) Inhibitors: PDE5-inhibitors are also vasodilators. (अल्फुज़ोसिन लेबल, चेतावनियां और सावधानियां)

Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants • Monoamine oxidase (MAO) inhibitors • Catechol-O-methyl transferase (COMT)… (एड्रेनालिन लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (टैम्सुलोसिन लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Alpha-adrenergic antagonists and PDE-5 inhibitors are both vasodilators that can lower blood pressure. (ड्यूटास्टेराइड और टैम्सुलोसिन लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. (पोटैशियम क्लोराइड लेबल, दवाओं के इंटरैक्शन)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)

Bronchospasm Like other inhaled prostaglandins, Tyvaso may cause acute bronchospasm. (ट्रेप्रोस्टिनिल लेबल, चेतावनियां और सावधानियां)

Post injury arterial injection of vasodilators and/or arterial infusion of parenteral fluids are generally regarded to be of no value in altering outcome. (मेथोहेक्सिटल लेबल, चेतावनियां)

Alpha-adrenergic blockers and PDE5 inhibitors are both vasodilators that can lower blood pressure. (सिलोडोसिन लेबल, चेतावनियां और सावधानियां)

Effect of Other Drugs on Treprostinil Drug interaction studies have been carried out with treprostinil (oral or subcutaneous) co-administered with acetaminophen (4 g/day), warfarin (25 mg/day), and fluconazole (200 mg/day), respectively, in healthy volunteers. (ट्रेप्रोस्टिनिल लेबल, दवाओं के इंटरैक्शन)