एलोप्यूरिनॉल और क्विनीन का इंटरैक्शन

Theophylline or Aminophylline In 20 healthy subjects who received multiple doses of quinine sulfate (648 mg every 8 hours x 7 days) with a single 300 mg oral dose of theophylline, the quinine mean C max and AUC were increased by 13% and 14% respectively.

Although no change in the quinine sulfate dosage regimen is necessary with concomitant theophylline or aminophylline, patients should be monitored closely for adverse reactions associated with quinine.

Theophylline or Aminophylline (CYP1A2 Substrate) In 19 healthy subjects who received multiple doses of quinine sulfate 648 mg every 8 hours x 7 days with a single 300 mg oral dose of theophylline, the mean theophylline AUC was 10% lower than when theophylline was given alone.

Therefore, if quinine sulfate is co-administered to patients receiving theophylline or aminophylline, plasma theophylline concentrations should be monitored frequently to ensure therapeutic concentrations.

There was no significant effect on mean theophylline C max .