एनास्ट्रोज़ोल और टैमोक्सीफेन का इंटरैक्शन

• Tamoxifen: Do not use in combination with ARIMIDEX.

Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with anastrozole.

• In women with pre-existing ischemic heart disease, an increased incidence of ischemic cardiovascular events occurred with ARIMIDEX use compared to tamoxifen use.

Ischemic Cardiovascular Events In women with pre-existing ischemic heart disease, an increased incidence of ischemic cardiovascular events was observed with ARIMIDEX in the ATAC trial (17% of patients on ARIMIDEX and 10% of patients on tamoxifen).

Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline.

Anastrozole and letrozole: Should not be used in combination with tamoxifen.

In the ATAC trial, coadministration of anastrozole and tamoxifen in breast cancer patients reduced the anastrozole plasma concentration by 27% compared to that achieved with anastrozole alone.

Aromatase Inhibitors Anastrozole The combination of anastrozole and tamoxifen did not demonstrate any benefit when compared to tamoxifen alone and should be avoided in all patients [see Clinical Studies (14.2) ] .