कार्बामाज़ेपिन और क्लोरप्रोमाज़िन का इंटरैक्शन

CNS Depressants The concomitant use of EQUETRO and other CNS depressants can increase the risk of respiratory depression, profound sedation, hypotension, and syncope.

Increased Intraocular Pressure Carbamazepine has mild anticholinergic activity.

Consider reducing the dose of CNS depressants or EQUETRO when using these drugs concomitantly.

Cytochrome (CYP) 3A4 inhibitors, epoxide hydrolase inhibitors, CYP3A4 inducers, drugs metabolized by CYP1A2 or CYP3A4 (oral contraceptives, delavirdine, nefazodone), phenytoin, CNS depressants, lithium, chloroquine, mefloquine ( 7.1 , 7.2 , 7.3 )

CNS depressants include: alcohol, opioid analgesics, benzodiazepines, tricyclic antidepressants, sedative/hypnotics, anticonvulsants, antipsychotics, antihistamines, anticholinergics, alpha and beta blockers, general anesthetics, muscle relaxants, and illicit CNS depressants.

Therefore, dosage of anticonvulsants, including barbiturates, should not be reduced if chlorpromazine is started.

Chlorpromazine may lower the convulsive threshold; dosage adjustments of anticonvulsants may be necessary.

Note: Chlorpromazine does not intensify the anticonvulsant action of barbiturates.

Potentiation of anticonvulsant effects does not occur.