कैस्पोफंगिन और साइक्लोस्पोरिन का इंटरैक्शन

• Elevated Liver Enzymes during Concomitant use with Cyclosporine: Limit use to patients for whom potential benefit outweighs potential risk.

Only use Caspofungin acetate for Injection and cyclosporine in those patients for whom the potential benefit outweighs the potential risk.

Cyclosporine : In two adult clinical studies, cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses) increased the AUC of caspofungin acetate for injection.

Caspofungin acetate for injection did not increase the plasma levels of cyclosporine.

There were transient increases in liver ALT and AST when caspofungin acetate for injection and cyclosporine were co-administered.