क्लोरोथायज़ाइड और एथाक्रिनिक एसिड का इंटरैक्शन

CONTRAINDICATIONS All diuretics, including ethacrynic acid, are contraindicated in anuria.

If increasing electrolyte imbalance, azotemia, and/or oliguria occur during treatment of severe, progressive renal disease, the diuretic should be discontinued.

In a few patients this diuretic has produced severe, watery diarrhea.

Like other diuretics it may precipitate hepatic coma and death.

A number of possibly drug-related deaths have occurred in critically ill patients refractory to other diuretics.

Thiazides may add to or potentiate the action of other antihypertensive drugs.

Lithium generally should not be given with diuretics (see PRECAUTIONS , Drug Interactions ).

Other Antihypertensive Drugs - additive effect or potentiation.

Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.

Non-steroidal Anti-inflammatory Drugs (NSAIDs) Including Selective Cyclooxygenase-2 (COX-2) Inhibitors - In some patients, the administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.