डेसोनाइड और डोसेटैक्सेल का इंटरैक्शन

Severe hypersensitivity reactions characterized by generalized rash/erythema, hypotension and/or bronchospasm, or fatal anaphylaxis, have been reported in patients premedicated with 3 days of corticosteroids.

All patients should be premedicated with an oral corticosteroid prior to the initiation of the infusion of Docetaxel Injection [ see Dosage and Administration (2.6) ].

Patients should be premedicated with oral corticosteroids prior to each Docetaxel Injection administration to reduce the incidence and severity of fluid retention [ see Dosage and Administration (2.6) ].

Among 92 breast cancer patients premedicated with 3-day corticosteroids, there were no cases of severe skin toxicity reported and no patient discontinued docetaxel due to skin toxicity.

Among 92 breast cancer patients premedicated with 3-day corticosteroids, moderate fluid retention occurred in 27.2% and severe fluid retention in 6.5%.