डाइफ्लुनिसाल और फ्यूरोसेमाइड का इंटरैक्शन

• Salicylates : Risk of salicylate toxicity ( 7.1 )

Salicylates May experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Monitor for symptoms of salicylate toxicity.

Diuretics Clinical studies, as well as postmarketing observations, have shown that diflunisal can reduce the natriuretic effect of furosemide and thiazides in some patients.

Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, patients who are volume depleted, and the elderly.

Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs.

Use of diflunisal may blunt the CV effects of several therapeutic agents used to treat these medical conditions [e.g., diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs)] (see Drug Interactions ).

Drug Interactions ACE-inhibitors and Angiotensin II Anagonists Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors and angiotensin II antagonists.