डिगॉक्सिन और लैपाटिनिब का इंटरैक्शन

These conditions include patients with hypokalemia or hypomagnesemia, with congenital long QT syndrome, patients taking antiarrhythmic medicines or other medicinal products with known risk for QT prolongation/ Torsades de Pointes, and cumulative high-dose anthracycline therapy.

Digoxin : Following coadministration of TYKERB and digoxin (P-gp substrate), systemic AUC of an oral digoxin dose increased approximately 2.8-fold.

Serum digoxin concentrations should be monitored prior to initiation of TYKERB and throughout coadministration.

If digoxin serum concentration is greater than 1.2 ng/mL, the digoxin dose should be reduced by half.