डिगॉक्सिन और प्रोपाफेनोन का इंटरैक्शन

• The applicability of the CAST results to other populations (e.g., those without recent myocardial infarction) or other antiarrhythmic drugs is uncertain, but at present, it is prudent to consider any IC antiarrhythmic to have a significant proarrhythmic risk in patients with structural heart disease.

• Avoid use with other antiarrhythmic agents or drugs that prolong the QT interval.

• Propafenone may increase digoxin or warfarin levels.

Digoxin Concomitant use of propafenone and digoxin increased steady-state serum digoxin exposure (AUC) in patients by 60% to 270% and decreased the clearance of digoxin by 31% to 67%.

Monitor plasma digoxin levels of patients receiving propafenone and adjust digoxin dosage as needed.