ड्रोनेडेरोन और फेलोडिपिन का इंटरैक्शन

• Calcium channel blockers (CCB): Initiate CCB with low dose and increase after ECG verification of tolerability.

Calcium Channel Blockers Calcium channel blockers with depressant effects on the sinus and AV nodes could potentiate dronedarone's effects on conduction.

Give a low dose of calcium channel blockers initially and increase only after ECG verification of good tolerability [see Drug Interactions (7.3) , Clinical Pharmacology (12.3) ] .

Calcium Channel Blockers Verapamil and diltiazem are moderate CYP3A inhibitors and increase dronedarone exposure.

Calcium Channel Blockers Dronedarone increased the exposure of calcium channel blockers (verapamil, diltiazem or nifedipine).

Coadministration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism.

Caution should be used when CYP3A4 inhibitors are coadministered with felodipine.

Drug Interactions CYP3A4 Inhibitors - Felodipine is metabolized by CYP3A4.

These effects have been observed with coadministration of itraconazole (a potent CYP3A4 inhibitor).