एर्लोटिनिब और ओमेप्राज़ोल और सोडियम बाइकार्बोनेट का इंटरैक्शन

For proton pump inhibitors, avoid concomitant use if possible.

For proton pump inhibitors avoid concomitant use if possible.

Drugs the Increase Gastric pH Co-administration of erlotinib with proton pump inhibitors (e.g., omeprazole) and H-2 receptor antagonists (e.g., ranitidine) decreased erlotinib exposure [see Clinical Pharmacology (12.3) ].

For H-2 receptor antagonists and antacids, modify the dosing schedule [see Dosage and Administration (2.4) ].

For use with antacids, separate dosing by several hours.

Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Omeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.