एस्सिटालोप्राम और पिमोज़ाइड का इंटरैक्शन

Taking pimozide because of the risk of QT prolongation [see Drug Interactions ( 7 )] .

Concomitant use of pimozide ( 4 , 7)

Pimozide Prevention or Management Escitalopram Capsules are contraindicated in patients taking pimozide [see Contraindications ( 4 )] .

Mechanism and Clinical Effect(s) Concomitant use of racemic citalopram with pimozide increases plasma concentrations of pimozide, a drug with a narrow therapeutic index, and may increase the risk of QT prolongation and/or ventricular arrhythmias compared to use of racemic citalopram alone.

Concomitant use in patients taking Celexa or Lexapro is contraindicated (see PRECAUTIONS - DRUG INTERACTIONS - Pimozide and Celexa ).

Concomitant use of Pimozide and Celexa or Lexapro is contraindicated (See CONTRAINDICATIONS ).

Because pimozide prolongs the QT interval of the electrocardiogram it is contraindicated in patients with congenital long QT syndrome, patients with a history of cardiac arrhythmias, patients taking other drugs which prolong the QT interval of the electrocardiogram or patients with known hypokalemia or hypomagnesemia (see also PRECAUTIONS - DRUG INTERACTIONS ).

DRUG INTERACTIONS Because pimozide prolongs the QT interval of the electrocardiogram, an additive effect on QT interval would be anticipated if administered with other drugs, such as phenothiazines, tricyclic antidepressants or antiarrhythmic agents, which prolong the QT interval.