फ्लिबैनसेरिन और प्रिमिडोन का इंटरैक्शन

Preventing or Managing DI The concomitant use of ADDYI with CYP3A4 inducers is not recommended.

• CYP3A4 Inducers : Use of ADDYI not recommended; flibanserin concentrations substantially reduced (7)

Exacerbated by other CNS depressants, and in settings where flibanserin concentrations are increased.

The risk of CNS depression is increased if ADDYI is taken during waking hours, or if ADDYI is taken with alcohol or other CNS depressants, or with medications that increase flibanserin concentrations, such as CYP3A4 inhibitors [see Contraindications (4), Warnings and Precautions (5.1, 5.2), Adverse Reactions (6.1) , and Drug Interactions (7) ].

Other CNS Depressants Examples Diphenhydramine, opioids, hypnotics, benzodiazepines Clinical Implications The concomitant use of ADDYI with CNS depressants may increase the risk of CNS depression (e.g., somnolence) compared to the use of ADDYI alone.