फ्लुड्रोकॉर्टिसोन और नैटालिज़ुमैब का इंटरैक्शन

Chicken pox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids.

Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles and, if exposed, to obtain medical advice.

Children who are on immunosuppressant drugs are more susceptible to infections than healthy children.

In Studies MS1 and MS2, an increase in infections was seen in patients concurrently receiving short courses of corticosteroids.

However, the increase in infections in natalizumab-treated patients who received steroids was similar to the increase in placebo-treated patients who received steroids.

In Studies CD1 and CD2, an increase in infections was seen in patients concurrently receiving corticosteroids.

However, the increase in infections was similar in placebo-treated and natalizumab-treated patients who received steroids.

…receiving natalizumab products should not be treated with concomitant immunosuppressants (e.g., 6‑ mercaptopurine, azathioprine, cyclosporine, or methotrexate) or inhibitors of TNF-α, and corticosteroids should be tapered in those patients with Crohn’s disease who are on chronic corticosteroids when they start TYRUKO therapy [see Indications and Usage ( 1.2 ) and Warnings…