फ्लुवोक्सामिन और मेटोप्रोलोल और हाइड्रोक्लोरोथायज़ाइड का इंटरैक्शन

Propranolol or metoprolol : Reduce dose if coadministered and titrate more cautiously ( 7.3 ).

One case of bradycardia and hypotension and a second case of orthostatic hypotension have been reported with the coadministration of fluvoxamine maleate and metoprolol.

Also, patients taking diuretics or who are otherwise volume depleted may be at greater risk.

Propranolol and Other Beta-Blockers: Coadministration of fluvoxamine maleate 100 mg per day and propranolol 160 mg per day in normal volunteers resulted in a mean five-fold increase (range 2 to 17) in minimum propranolol plasma concentrations.

If propranolol or metoprolol is coadministered with Fluvoxamine Maleate Tablets, a reduction in the initial beta-blocker dose and more cautious dose titration are recommended.