फ्लुवोक्सामिन और रोपिवाकेन का इंटरैक्शन

Thus strong inhibitors of cytochrome P4501A2, such as fluvoxamine, given concomitantly during administration of NAROPIN, can interact with NAROPIN leading to increased ropivacaine plasma levels.

In vivo, the plasma clearance of ropivacaine was reduced by 70% during coadministration of fluvoxamine (25 mg bid for 2 days), a selective and potent CYP1A2 inhibitor.

Caution should be exercised when CYP1A2 inhibitors are coadministered.