हेलोपेरिडोल और नेफाज़ोडोन का इंटरैक्शन

The effect of CYP3A4 inhibition and of decreased CYP2D6 enzyme may be additive.

Plasma concentrations of CYP2D6 substrates (e,g. tricyclic antidepressants such as desipramine or imipramine) may increase when they are co-administered with haloperidol.

Examples include: CYP3A4 inhibitors – alprazolam; itraconazole, ketoconazole, nefazodone, ritonavir.

Haloperidol – When a single oral 5 mg dose of haloperidol was coadministered with nefazodone (200 mg BID) at steady state, haloperidol apparent clearance decreased by 35% with no significant increase in peak haloperidol plasma concentrations or time of peak.

Dosage adjustment of haloperidol may be necessary when coadministered with nefazodone.

Pharmacodynamic effects of haloperidol were generally not altered significantly.

Some cases presented with features resembling neuroleptic malignant syndrome.