इरिनोटेकन और फेनोबार्बिटोन, हायोसायमिन, एट्रोपिन और स्कोपोलामाइन (हायोसिन) का इंटरैक्शन

Early diarrhea may be accompanied by cholinergic symptoms which may be prevented or ameliorated by atropine.

Consider prophylactic or therapeutic administration of 0.25 mg to 1 mg of intravenous or subcutaneous atropine (unless clinically contraindicated).

Strong CYP3A4 Inducers Exposure to irinotecan or its active metabolite SN-38 is substantially reduced in adult and pediatric patients concomitantly receiving the CYP3A4 enzyme-inducing anticonvulsants phenytoin, phenobarbital, carbamazepine, or St.