इट्राकोनाज़ोल और टेल्मिसार्टन और एम्लोडिपिन का इंटरैक्शन

Calcium Channel Blockers Felodipine Nisoldipine Contraindicated during and 2 weeks after TOLSURA treatment.

Calcium channel blockers can have negative inotropic effects which may be additive to those of itraconazole.

Therefore, when co-administering itraconazole and calcium channel blockers, monitor carefully for signs and symptoms of CHF during treatment due to an increased risk of CHF.

Diltiazem Other dihydropyridines Verapamil Monitor for adverse reactions.

Calcium Channel Blockers Diltiazem Monitor for adverse reactions.

CYP3A4 Inhibitors Co-administration of a 180 mg daily dose of diltiazem with 5 mg amlodipine in elderly hypertensive patients resulted in a 60% increase in amlodipine systemic exposure.

However, strong inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, ritonavir) may increase the plasma concentrations of amlodipine to a greater extent.

Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A4 inhibitors.