लेवोनॉरजेस्ट्रेल और नॉरजेस्टिमेट और एथिनिल एस्ट्राडियोल का इंटरैक्शन

…Precautions ( 5.4 )] • Postpartum endometritis or infected abortion in the past 3 months • Known or suspected uterine or cervical malignancy • Known or suspected breast cancer or other progestin-sensitive cancer, now or in the past • Uterine bleeding of unknown etiology • Untreated acute cervicitis or vaginitis, including bacterial vaginosis or other lower genital…

• Known or suspected breast cancer or other progestin-sensitive cancer ( 4 )

• Uterine perforation may occur and may reduce contraceptive effectiveness or require surgery.

In addition, perforation may reduce contraceptive efficacy and result in pregnancy.

• Partial or complete expulsion may occur, which can be unnoticed, leading to loss of contraceptive efficacy.

Effects of Other Drugs on Combined Oral Contraceptives Substances decreasing the plasma concentrations of COCs Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of COCs and potentially diminish the effectiveness of COCs or increase breakthrough bleeding.