लोफेक्सिडिन और नाल्मेफीन का इंटरैक्शन

Risk of Recurrent Respiratory and CNS Depression : A recurrence of respiratory depression is possible, therefore, keep the patient under continued surveillance and administer repeat doses of ZURNAI using a new auto-injector with each dose while awaiting emergency medical assistance.

Oral Naltrexone : Concomitant use may reduce efficacy of oral naltrexone.

It is possible that oral naltrexone efficacy may be reduced if used concomitantly within 2 hours of Lofexidine tablets.

Oral Naltrexone Coadministration of Lofexidine tablets and oral naltrexone resulted in statistically significant differences in the steady-state pharmacokinetics of naltrexone.

This interaction is not expected if naltrexone is administered by non-oral routes [see Clinical Pharmacology (12.3) ] .