मेटोप्रोलोल और हाइड्रोक्लोरोथायज़ाइड और वेनलाफैक्सिन का इंटरैक्शन

Caution should be exercised with co-administration of venlafaxine and metoprolol.

Metoprolol - Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30-40% without altering the plasma concentrations of its active…

Also, patients taking diuretics or who are otherwise volume-depleted may be at greater risk [see Use in Specific Populations ( 8.5 )] .

Metoprolol: Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.

Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol in this study.