नालबुफिन और नाल्डेमेडिन का इंटरैक्शन

Management of respiratory depression may include close observation, supportive measures, and use of opioid overdose reversal agents (e.g., naloxone, nalmefene), depending on the patient's clinical status [see OVERDOSAGE ].

Naloxone may reverse these effects.

Maternal administration of naloxone during labor has normalized these effects in some cases.

Drug Interactions Benzodiazepines and other Central Nervous System (CNS) Depressants Although Nalbuphine Hydrochloride Injection possesses opioid antagonist activity, there is evidence that in nondependent patients it will not antagonize an opioid analgesic administered just before, concurrently, or just after an injection of Nalbuphine Hydrochloride Injection.

Intervention Avoid use of SYMPROIC with another opioid antagonist.

Other opioid antagonists : Potential for additive effect and increased risk of opioid withdrawal; avoid concomitant use ( 7 )

Opioid withdrawal : Consider the overall risk benefit in patients with disruptions to the blood-brain barrier.

Monitor symptoms of opioid withdrawal ( 5.2 )

Opioid Withdrawal Clusters of symptoms consistent with opioid withdrawal, including hyperhidrosis, chills, increased lacrimation, hot flush/flushing, pyrexia, sneezing, feeling cold, abdominal pain, diarrhea, nausea, and vomiting have occurred in patients treated with SYMPROIC [see Adverse Reactions (6.1) ] .