नेप्रोक्सेन और एसोमेप्राज़ोल और राल्टेग्राविर का इंटरैक्शन

• Decreased exposure of some antiretroviral drugs (e.g., rilpivirine, atazanavir, and nelfinavir) when used concomitantly with esomeprazole magnesium may reduce antiviral effect and promote the development of drug resistance [see Clinical Pharmacology (12.3) ].

• Increased exposure of other antiretroviral drugs (e.g., saquinavir) when used concomitantly with esomeprazole magnesium may increase toxicity [see Clinical Pharmacology (12.3) ].

Antiretrovirals Clinical Impact : The effect of esomeprazole magnesium on antiretroviral drugs is variable.

• There are other antiretroviral drugs which do not result in clinically relevant interactions with esomeprazole magnesium.

Other antiretrovirals : See prescribing information of specific drugs.

Based on these data, ISENTRESS is not expected to affect the pharmacokinetics of drugs that are substrates of these enzymes or P-glycoprotein (e.g., protease inhibitors, NNRTIs, opioid analgesics, statins, azole antifungals, proton pump inhibitors and anti-erectile dysfunction agents).