प्रैमिपेक्सोल और टोलकैपोन का इंटरैक्शन

Tolcapone tablets is also contraindicated in patients with a history of nontraumatic rhabdomyolysis or hyperpyrexia and confusion possibly related to medication (see PRECAUTIONS: Events Reported With Dopaminergic Therapy ).

PRECAUTIONS: Hypotension/Syncope: Dopaminergic therapy in Parkinson's disease patients has been associated with orthostatic hypotension.

Baseline treatment with dopamine agonists or selegiline did not appear to increase the likelihood of experiencing orthostatic hypotension when treated with Tolcapone tablets.

Dyskinesia: Tolcapone tablets may potentiate the dopaminergic side effects of levodopa and may cause and/or exacerbate preexisting dyskinesia.

These reports are associated with patients taking Tolcapone tablets in conjunction with carbidopa/levodopa, as well as other medications that increase central dopaminergic tone and that are used to treat patients with Parkinson’s disease.