प्राज़ोसिन और वार्डेनाफिल का इंटरैक्शन

Concomitant administration of prazosin hydrochloride capsules with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension (see DOSAGE AND ADMINISTRATION ).

Alpha-Blockers : Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers.

Alpha-Blockers Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers.

Consideration should be given to the following: Patients should be stable on alpha-blocker therapy prior to initiating a PDE5 inhibitor.

Patients who demonstrate hemodynamic instability on alpha-blocker therapy alone are at increased risk of symptomatic hypotension with concomitant use of PDE5 inhibitors.

In those patients who are stable on alpha-blocker therapy, PDE5 inhibitors should be initiated at the lowest recommended starting dose [see Dosage and Administration (2.4) ] .