सोराफेनिब और वेरापामिल का इंटरैक्शन

Consider temporary or permanent discontinuation for severe or persistent hypertension despite antihypertensive therapy.

In cases of severe or persistent hypertension despite institution of antihypertensive therapy, consider temporary or permanent discontinuation of NEXAVAR [see Dosage and Administration ( 2.2 )] .

Monitor electrolytes and electrocardiograms in patients with congestive heart failure, bradyarrhythmias, drugs known to prolong the QT interval, including Class Ia and III antiarrhythmics.

Hypertension was usually mild to moderate, occurred early in the course of treatment, and was managed with standard antihypertensive therapy.