Abacavir and St. John's wort interaction
Abacavir and St. John's wort: NIH and FDA consumer guidance flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Major
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
Curated guidance for St. John's wort
Major
St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure.
Curated ruleNCCIH, St. John's Wort
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.