Interaction Checker

St. John's wort interactions

St. John's wort is one of the most interaction-prone supplements: it induces CYP3A4 and P-glycoprotein, lowering levels of many prescription drugs.

St. John's wort has 144 documented interactions across the FDA labels and fact sheets we index: 139 major, 3 moderate, 2 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This herbal and supplement page is a starting point, not a verdict for your situation.

Interactions from the label

Major interactions (139)

  • AbacavirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Abacavir and lamivudineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • AlmotriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • AlprazolambenzodiazepineMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Amitriptylinetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Amlodipinedihydropyridine calcium channel blockerMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Amoxapinetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • ApixabananticoagulantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • AtazanavirantiretroviralMajor

    John’s wort ( Hypericum perforatum ) Lipid-Modifying Agents: Lomitapide, lovastatin, simvastatin Phosphodiesterase-5 (PDE-5) Inhibitor Sildenafil b when dosed as REVATIO ® for the treatment of pulmonary arterial hypertension Protease Inhibitors Indinavir Non-nucleoside Reverse Transcriptase Inhibitors Nevirapine • In patients with previously demonstrated hypersensitivity… (Atazanavir label, Contraindications)

  • AtorvastatinstatinMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Bictegravir, emtricitabine, and tenofovir alafenamideantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Brompheniramine, pseudoephedrine, and dextromethorphanantihistamineMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • BupropionantidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Buspironeserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • CabotegravirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • CitalopramSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Clomipraminetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Conjugated estrogensestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Conjugated estrogens and bazedoxifeneestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Cyclobenzaprinemuscle relaxantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • CyclosporineimmunosuppressantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • DabigatrananticoagulantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • DarunavirantiretroviralMajor

    John's wort ( Hypericum perforatum ) Hepatitis C direct acting antiviral: elbasvir/grazoprevir Lipid modifying agents: lomitapide, lovastatin, simvastatin Opioid Antagonist: naloxegol PDE-5 inhibitor: sildenafil when used for treatment of pulmonary arterial hypertension Sedatives/hypnotics: orally administered midazolam, triazolam Co-administration of PREZISTA/ritonavir… (Darunavir label, Contraindications)

  • Darunavir and cobicistatantiretroviralMajor

    John's wort ( Hypericum perforatum ) Hepatitis C direct acting antiviral: elbasvir/grazoprevir Lipid modifying agents: lomitapide, lovastatin, simvastatin Opioid Antagonist: naloxegol PDE-5 inhibitor: sildenafil when used for treatment of pulmonary arterial hypertension Sedatives/hypnotics: orally administered midazolam, triazolam PREZCOBIX or PREZCOBIX PED is… (Darunavir and cobicistat label, Contraindications)

  • Desipraminetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Desogestrel and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • DesvenlafaxineSNRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Dextromethorphanserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Dextromethorphan and quinidineserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Digoxindigitalis glycosideMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Dihydroergotamineergot alkaloidMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • DolutegravirantiretroviralMajor

    John’s wort ( Hypericum perforatum ) ↓Dolutegravir Avoid coadministration with TIVICAY or TIVICAY PD because there are insufficient data to make dosing recommendations. (Dolutegravir label, Drug interactions)

  • DoravirineantiretroviralMajor

    John's wort ( Hypericum perforatum) PIFELTRO is contraindicated when co-administered with drugs that are strong cytochrome P450 (CYP)3A enzyme inducers as significant decreases in doravirine plasma concentrations may occur, which may decrease the effectiveness of PIFELTRO. (Doravirine label, Contraindications)

  • Doxepintricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Drospirenone and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • DuloxetineSNRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • EdoxabananticoagulantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • EfavirenzantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Efavirenz, lamivudine, and tenofovirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • EletriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Elvitegravir, cobicistat, emtricitabine, and tenofovirantiretroviralMajor

    John's wort ( Hypericum perforatum ) Lipid-modifying Agents: lomitapide, lovastatin, simvastatin Phosphodiesterase-5 (PDE-5) Inhibitor: sildenafil when administered as REVATIO ® for the treatment of pulmonary arterial hypertension Sedative/hypnotics: triazolam, orally administered midazolam Coadministration of GENVOYA is contraindicated with drugs that: Are highly… (Elvitegravir, cobicistat, emtricitabine, and tenofovir label, Contraindications)

  • EmtricitabineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Emtricitabine and tenofovirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Emtricitabine, rilpivirine, and tenofovirantiretroviralMajor

    …oxcarbazepine, phenobarbital, phenytoin Antimycobacterials: rifampin, rifapentine Glucocorticoid (systemic): dexamethasone (more than a single-dose) Herbal Products: St John's wort ( Hypericum perforatum ) Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole COMPLERA is contraindicated when coadministered… (Emtricitabine, rilpivirine, and tenofovir label, Contraindications)

  • EscitalopramSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Esterified estrogens and methyltestosteroneestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • EstradiolestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Estradiol and dienogestoral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Estradiol and norethindroneestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Ethynodiol diacetate and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Etonogestrel and ethinyl estradiolestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • EtravirineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • EverolimusimmunosuppressantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Felodipinedihydropyridine calcium channel blockerMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • FentanylopioidMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • FlibanserinCNS depressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • FluoxetineSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • FluvoxamineSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • FosamprenavirantiretroviralMajor

    John’s wort ( Hypericum perforatum ) Lipid modifying agents: Lomitapide, lovastatin, simvastatin Non-nucleoside reverse transcriptase inhibitor: Delavirdine PDE5 inhibitor: Sildenafil (Revatio) (for treatment of pulmonary arterial hypertension) Sedative/hypnotics: Midazolam, triazolam Hypersensitivity to fosamprenavir calcium or amprenavir (e.g., Stevens-Johnson… (Fosamprenavir label, Contraindications)

  • FrovatriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • FulvestrantestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • GranisetronQT-prolonging drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • ImatinibCYP3A4 inhibitorMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Imipraminetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • IsoniazidantibioticMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • IvabradineMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • LamivudineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Lamivudine and zidovudineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Lansoprazoleproton pump inhibitorMajor

    Intervention: St John's Wort, rifampin : Avoid concomitant use with PREVACID or PREVACID SoluTab. (Lansoprazole label, Drug interactions)

  • LenacapavirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • LevomilnacipranSNRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • LevonorgestrelprogestinMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Levonorgestrel and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • LinezolidantibioticMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Lithiumserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Lopinavir and ritonavirantiretroviralMajor

    John's Wort (hypericum perforatum) Hypersensitivity to KALETRA (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, urticaria, angioedema) or any of its ingredients, including ritonavir. (Lopinavir and ritonavir label, Contraindications)

  • LovastatinstatinMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • MaravirocantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • MedroxyprogesteroneprogestinMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • MegestrolprogestinMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • MeperidineopioidMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • MethadoneopioidMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Methylene blueMAO inhibitorMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • MidazolambenzodiazepineMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • MifepristoneCYP3A4 inhibitorMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • MilnacipranSNRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • MirtazapineantidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Naltrexone and bupropionopioid antagonistMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • NaratriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • NefazodoneantidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • NevirapineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • Nifedipinedihydropyridine calcium channel blockerMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • Nirmatrelvir and ritonavirantiviralMajor

    John's Wort ( hypericum perforatum ) • History of clinically significant hypersensitivity reactions to the active ingredients (nirmatrelvir or ritonavir) or any other components. (Nirmatrelvir and ritonavir label, Contraindications)

  • Norelgestromin and ethinyl estradiolestrogenMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • NorethindroneprogestinMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Norethindrone and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Norgestimate and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Norgestrel and ethinyl estradioloral contraceptiveMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Nortriptylinetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Olanzapine and fluoxetineantipsychoticMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • OndansetronQT-prolonging drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • OxycodoneopioidMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • PalbociclibCYP3A4 inhibitorMajor

    Avoid concomitant use of strong CYP3A inducers (e.g., phenytoin, rifampin, carbamazepine, enzalutamide, and St John's Wort) [see Clinical Pharmacology (12.3) ] . (Palbociclib label, Drug interactions)

  • Palonosetronserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • ParoxetineSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • PhenelzineMAO inhibitorMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • ProgesteroneprogestinMajor

    St. John's wort can make birth control pills less effective. (NCCIH, St. John's Wort)

  • Promethazine and dextromethorphanantihistamineMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Protriptylinetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Prucaloprideserotonergic drugMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • RaltegravirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • RasagilineMAO inhibitorMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • RilpivirineantiretroviralMajor

    John's wort ( Hypericum perforatum ) Proton Pump Inhibitors e.g., Esomeprazole Lansoprazole Omeprazole Pantoprazole Rabeprazole Potential for significant decreases in rilpivirine plasma concentrations due to gastric pH increase, which may result in loss of virologic response. (Rilpivirine label, Contraindications)

  • RitonavirantiretroviralMajor

    John's Wort (hypericum perforatum) NORVIR is contraindicated in patients with known hypersensitivity to ritonavir (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome) or any of its ingredients ( 4 ) (Ritonavir label, Contraindications)

  • RivaroxabananticoagulantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • RizatriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • SelegilineMAO inhibitorMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • SertralineSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • SimvastatinstatinMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • SirolimusimmunosuppressantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • SolriamfetolCNS stimulantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • SumatriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Sumatriptan and naproxentriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • TacrolimusimmunosuppressantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • TapentadolopioidMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • TenofovirantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • TramadolopioidMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Tramadol and acetaminophenopioidMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • TranylcypromineMAO inhibitorMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • TrazodoneantidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Trimipraminetricyclic antidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • VenlafaxineSNRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Verapamilcalcium channel blockerMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • VilazodoneSSRIMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • VortioxetineantidepressantMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • WarfarinanticoagulantMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

  • ZidovudineantiretroviralMajor

    St. John's wort can lower blood levels of some HIV medicines enough to cause treatment failure. (NCCIH, St. John's Wort)

  • ZolmitriptantriptanMajor

    Combining St. John's wort with antidepressants and other serotonergic drugs increases the risk of serotonin syndrome. (NCCIH, St. John's Wort)

  • Zolpidemsedative-hypnoticMajor

    St. John's wort can weaken these medicines by speeding up their breakdown, which can mean organ rejection, clots, or loss of effect. (NCCIH, St. John's Wort)

Moderate interactions (3)

  • Elexacaftor, tezacaftor, and ivacaftorModerate

    John's wort ( Hypericum perforatum ) Strong or Moderate CYP3A Inhibitors The dosage of TRIKAFTA should be reduced when used concomitantly with strong CYP3A inhibitors [see Dosage and Administration (2.4) and Warnings and Precautions (5.6) ] . (Elexacaftor, tezacaftor, and ivacaftor label, Drug interactions)

  • NateglinidemeglitinideModerate

    Drugs and Herbals That May Reduce the Blood-Glucose-Lowering Effect of Nateglinide and Increase Susceptibility to Hyperglycemia Drugs: Thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogues (e.g., lanreotide, octreotide), and CYP inducers (e.g., rifampin, phenytoin and St John's Wort). (Nateglinide label, Drug interactions)

  • TheophyllinemethylxanthineModerate

    John’sWort (Hypericum Perforatum) Decrease in theophylline plasma concentrations. (Theophylline label, Drug interactions)

Minor mentions (2)

  • HaloperidolantipsychoticMinor

    Examples include (but are not limited to): carbamazepine, phenobarbital, phenytoin, rifampin, St John's Wort ( Hypericum, perforatum ). (Haloperidol label, Drug interactions)

  • Ledipasvir and sofosbuvirantiviralMinor

    John's wort (Hypericum perforatum) ↓ ledipasvir ↓ sofosbuvir Coadministration of ledipasvir and sofosbuvir with St. (Ledipasvir and sofosbuvir label, Drug interactions)

Check St. John's wort against everything you take. Add your full list; every pair is checked at once.

Open in the checker

Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.