Abiraterone and Methylprednisolone interaction
Abiraterone and Methylprednisolone: the Abiraterone prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Abiraterone (ABIRATERONE ACETATE) label · effective 2026-06-16
Increased fractures and mortality in combination with radium Ra 223 dichloride: Use of YONSA plus methylprednisolone in combination with radium Ra 223 dichloride is not recommended.
Increased Fractures and Mortality in Combination with Radium Ra 223 Dichloride Abiraterone Acetate plus methylprednisolone is not recommended for use in combination with radium Ra 223 dichloride outside of clinical trials.
At the primary analysis, increased incidences of fractures (28.6% vs 11.4%) and deaths (38.5% vs 35.5%) have been observed in patients who received abiraterone acetate plus a corticosteroid in combination with radium Ra 223 dichloride compared to patients who received placebo in combination with abiraterone acetate plus a corticosteroid.
Increased dosage of corticosteroids may be indicated before, during and after stressful situations.
Monitor patients for symptoms and signs of adrenocortical insufficiency, particularly if patients are withdrawn from corticosteroids, have corticosteroid dose reductions, or experience unusual stress.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.