एबिराटेरोन और मिथाइलप्रेडनिसोलोन का इंटरैक्शन

Increased fractures and mortality in combination with radium Ra 223 dichloride: Use of YONSA plus methylprednisolone in combination with radium Ra 223 dichloride is not recommended.

Increased Fractures and Mortality in Combination with Radium Ra 223 Dichloride Abiraterone Acetate plus methylprednisolone is not recommended for use in combination with radium Ra 223 dichloride outside of clinical trials.

At the primary analysis, increased incidences of fractures (28.6% vs 11.4%) and deaths (38.5% vs 35.5%) have been observed in patients who received abiraterone acetate plus a corticosteroid in combination with radium Ra 223 dichloride compared to patients who received placebo in combination with abiraterone acetate plus a corticosteroid.

Increased dosage of corticosteroids may be indicated before, during and after stressful situations.

Monitor patients for symptoms and signs of adrenocortical insufficiency, particularly if patients are withdrawn from corticosteroids, have corticosteroid dose reductions, or experience unusual stress.