Acetaminophen and codeine and Metyrapone interaction
Acetaminophen and codeine and Metyrapone: the Metyrapone prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Metyrapone (Metopirone) label · effective 2026-05-19
Acetaminophen: Avoid concomitant use with Metopirone.
Avoid concomitant use of Metopirone with acetaminophen.
Effect of Metopirone on Other Drugs Acetaminophen Metopirone inhibits the glucuronidation of acetaminophen, which may decrease elimination of acetaminophen and lead to increased risk of adverse reactions related to acetaminophen.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.