Acitretin and Megestrol interaction
Acitretin and Megestrol: the Acitretin prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Acitretin label · effective 2026-08-05
It has not been established if there is a pharmacokinetic interaction between acitretin and combined oral contraceptives.
However, it has been established that acitretin interferes with the contraceptive effect of microdosed progestin preparations.
Microdosed “minipill” progestin preparations are not recommended for use with acitretin.
It is not known whether other progestin-only contraceptives, such as implants and injectables, are adequate methods of contraception during acitretin therapy .
Prescribers are advised to consult the package insert of any medication administered concomitantly with hormonal contraceptives, since some medications may decrease the effectiveness of these birth control products.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.