Acitretin and Tretinoin interaction
Acitretin and Tretinoin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Tretinoin label · effective 2026-05-26
Tretinoin capsules are contraindicated in patients with a known hypersensitivity to tretinoin capsules, any of its components, or other retinoids.
Hypersensitivity to tretinoin capsules, any of its components, or other retinoids
From the Acitretin label · effective 2026-08-05
Acitretin is contraindicated in cases of hypersensitivity (e.g., angioedema, urticaria) to the preparation (acitretin or excipients) or to other retinoids .
Pseudotumor Cerebri: Acitretin and other retinoids administered orally have been associated with cases of pseudotumor cerebri (benign intracranial hypertension).
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.