Adenosine and Aminophylline interaction
Adenosine and Aminophylline: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Adenosine label · effective 2025-01-03
Use of methylxanthines (e.g., caffeine, aminophylline and theophylline) is not recommended in patients who experience a seizures in association with adenosine injection ( 5.6 )
Methylxanthine use is not recommended in patients who experience seizures in association with adenosine injection administration [see Overdosage (10) ].
Aminophylline may increase the risk of seizures associated with adenosine injection.
Methylxanthines interfere with the activity of adenosine ( 7.1 , 10 )
Effects of Other Drugs on Adenosine Injection The vasoactive effects of adenosine are inhibited by adenosine receptor antagonists, (such as methylxanthines (e.g., caffeine, aminophylline, and theophylline).
From the Aminophylline label · effective 2026-05-22
Higher doses of adenosine may be required to achieve desired effect.
25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.
Adenosine Theophylline blocks adenosine receptors.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.