एडेनोसिन और एमिनोफाइलिन का इंटरैक्शन

Use of methylxanthines (e.g., caffeine, aminophylline and theophylline) is not recommended in patients who experience a seizures in association with adenosine injection ( 5.6 )

Methylxanthine use is not recommended in patients who experience seizures in association with adenosine injection administration [see Overdosage (10) ].

Aminophylline may increase the risk of seizures associated with adenosine injection.

Methylxanthines interfere with the activity of adenosine ( 7.1 , 10 )

Effects of Other Drugs on Adenosine Injection The vasoactive effects of adenosine are inhibited by adenosine receptor antagonists, (such as methylxanthines (e.g., caffeine, aminophylline, and theophylline).

Higher doses of adenosine may be required to achieve desired effect.

25% increase Diazepam Benzodiazepines increase CNS concentrations of adenosine, a potent CNS depressant, while theophylline blocks adenosine receptors.

Adenosine Theophylline blocks adenosine receptors.