Aliskiren and Telmisartan interaction
Aliskiren and Telmisartan: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Aliskiren label · effective 2022-12-30
Do not use aliskiren with ARBs or ACEIs in patients with diabetes [see Warnings and Precautions (5.2) and Clinical Studies (14.3) ].
Do not use with angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs) in patients with diabetes.
Avoid concomitant use with ARBs or ACEIs particularly in patients with renal impairment [creatinine clearance (CrCl) <60 mL/min].
Renal Impairment/Hyperkalemia/Hypotension when Aliskiren Tablets are Given in Combination with ARBs or ACEIs Aliskiren tablets are contraindicated in patients with diabetes who are receiving ARBs or ACEIs because of the increased risk of renal impairment, hyperkalemia, and hypotension.
In general, avoid combined use of aliskiren with ACE inhibitors or ARBs, particularly in patients with creatinine clearance (CrCl) less than 60 mL/min [see Contraindications (4) , Drug Interactions (7) and Clinical Studies (14.3) ] .
From the Telmisartan label · effective 2026-01-28
Do not co-administer aliskiren with telmisartan in patients with diabetes [see Drug Interactions ( 7 )].
Do not co-administer aliskiren with telmisartan in patients with diabetes ( 4 )
Do not co-administer aliskiren with telmisartan tablets in patients with diabetes.
Avoid concomitant use of aliskiren with telmisartan tablets in patients with renal impairment (GFR <60 mL/min/1.73 m 2 ).
Aliskiren: Do not co-administer aliskiren with telmisartan in patients with diabetes.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.