Amlodipine and atorvastatin and Digoxin interaction
Amlodipine and atorvastatin and Digoxin: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Amlodipine and atorvastatin label · effective 2026-05-21
• Digoxin: May increase digoxin plasma levels; monitor patients appropriately ( 7.5 ).
Digoxin Clinical Impact: When multiple doses of atorvastatin and digoxin were co-administered, steady state plasma digoxin concentrations increased [see Clinical Pharmacology (12.3) ].
Intervention: Monitor patients taking digoxin appropriately.
From the Digoxin label · effective 2025-04-10
Beta-adrenergic Blockers and Calcium Channel Blockers Additive effects on AV node conduction can result in complete heart block.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.