Amoxicillin and clavulanate and Probenecid interaction
Amoxicillin and clavulanate and Probenecid: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Amoxicillin and clavulanate (Amoxicillin and Clavulanate Potassium) label · effective 2026-07-07
Co-administration with probenecid is not recommended.
Co-administration of probenecid is not recommended.
Probenecid Probenecid decreases the renal tubular secretion of amoxicillin.
From the Probenecid label · effective 2026-04-29
Drug Interactions When probenecid is used to elevate plasma concentrations of penicillin or other beta-lactams, or when such drugs are given to patients taking probenecid therapeutically, high plasma concentrations of the other drug may increase the incidence of adverse reactions associated with that drug.
In the case of penicillin or other beta-lactams, psychic disturbances have been reported.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.